Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 8/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.33 |
| ▸ | ITK | Q08881 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL740692 | 0.94 | HRH1 (0.35) | HRH1CYP2D6KCNH2HSD11B1ALDH1A1 | |
| SCHEMBL740379 | 0.89 | HRH1 (0.44) | HRH1CYP2D6KCNH2CHRM1CYP3A4 | |
| SCHEMBL739361 | 0.86 | HRH1 (0.35) | HRH1CYP2D6KCNH2HSD11B1ITK | |
| SCHEMBL739313 | 0.85 | HRH1 (0.44) | HRH1CYP2D6KCNH2CHRM1CYP3A4 | |
| SCHEMBL740452 | 0.85 | NLRP3 (0.37) | HRH1CYP2D6KCNH2ITKCHRM1 | |
| SCHEMBL762607 | 0.84 | KLK5 (0.35) | HRH1CYP2D6KCNH2HSD11B1ITK | |
| SCHEMBL742487 | 0.84 | HRH1 (0.36) | HRH1CYP2D6KCNH2PPARAALDH1A1 | |
| SCHEMBL741454 | 0.83 | HRH1 (0.36) | HRH1CYP2D6KCNH2PPARAALDH1A1 | |
| SCHEMBL742049 | 0.83 | HRH1 (0.35) | HRH1CYP2D6KCNH2HSD11B1PPARA | |
| SCHEMBL739588 | 0.81 | HRH1 (0.43) | HRH1CYP2D6KCNH2ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |