Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 16/20 | 0.43 |
| ▸ | ACHE | P22303 | 15/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7398143 | 0.89 | HTR4 (0.47) | HTR4ACHESIGMAR1 | |
| SCHEMBL6263176 | 0.84 | HTR4 (0.58) | HTR4ACHESIGMAR1 | |
| SCHEMBL7400947 | 0.81 | HTR4 (0.54) | HTR4ACHESIGMAR1 | |
| SCHEMBL7398774 | 0.76 | HTR4 (0.42) | HTR4ACHESIGMAR1 | |
| SCHEMBL7404756 | 0.73 | HTR4 (0.58) | HTR4ACHESIGMAR1 | |
| SCHEMBL6776570 | 0.72 | HTR4 (0.45) | HTR4ACHESIGMAR1 | |
| Hydrochloric Acid SCHEMBL7399150 | 0.72 | HTR2C (0.59) | HTR4ACHESIGMAR1 | |
| SCHEMBL7143630 | 0.70 | HTR4 (0.48) | HTR4ACHESIGMAR1 | |
| SCHEMBL8323554 | 0.69 | HTR4 (0.37) | HTR4ACHESIGMAR1 | |
| Hydrochloric Acid SCHEMBL8322605 | 0.68 | HTR4 (0.37) | HTR4ACHESIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0604494-B1 | 5-HT4 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1999-07-28 | — | — | EP | claimed |
| US-5580885-A | FOR TREATMENT OF GASTROINTESTINAL, CARDIOVASCULAR OR NERVOUS SYSTEM DISORDERS | SMITHKLINE BEECHAM P.L.C. (GB) | 1996-12-03 | — | — | US | claimed |
| EP-0604494-B1 | 5-HT4 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1999-07-28 | — | — | EP | disclosed |
| US-5580885-A | FOR TREATMENT OF GASTROINTESTINAL, CARDIOVASCULAR OR NERVOUS SYSTEM DISORDERS | SMITHKLINE BEECHAM P.L.C. (GB) | 1996-12-03 | — | — | US | disclosed |
| EP-0604494-A1 | 5-HT 4? RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-07-06 | — | — | EP | disclosed |
| WO-1993005038-A1 | 5-HT4 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1993-03-18 | — | — | WO | disclosed |