Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 11/20 | 0.53 |
| ▸ | CTSK | P43235 | 9/20 | 0.53 |
| ▸ | CTSB | P07858 | 5/20 | 0.53 |
| ▸ | CTSL | P07711 | 3/20 | 0.53 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | ACE | P12821 | 1/20 | 0.47 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6162390 | 0.87 | PTPN1 (0.54) | CTSSCTSKCTSBCTSLPTPN1 | |
| SCHEMBL6162397 | 0.87 | PTPN1 (0.54) | CTSSCTSKCTSBCTSLPTPN1 | |
| SCHEMBL28198598 | 0.82 | CTSS (0.57) | CTSSCTSKCTSBCTSLPOLB | |
| SCHEMBL28198599 | 0.82 | CTSS (0.57) | CTSSCTSKCTSBCTSLPOLB | |
| SCHEMBL10857658 | 0.82 | CTSS (0.57) | CTSSCTSKCTSBCTSLPOLB | |
| SCHEMBL3355326 | 0.82 | CTSS (0.64) | CTSSCTSKCTSBCTSLPOLB | |
| SCHEMBL85543 | 0.82 | CTSS (0.64) | CTSSCTSKCTSBCTSLPOLB | |
| SCHEMBL22404737 | 0.82 | CTSS (0.64) | CTSSCTSKCTSBCTSLPOLB | |
| SCHEMBL2617295 | 0.82 | PTPN1 (0.56) | CTSSCTSKCTSBCTSLPTPN1 | |
| SCHEMBL13707865 | 0.82 | PTPN1 (0.56) | CTSSCTSKCTSBCTSLPTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5861393-A | THROMBIN INHIBITORS; VASCULAR, CARDIOVASCULAR, NERVOUS SYSTEM AND BRAIN DISORDERS; ANTIISCHEMIC AND ANTIINFLAMMATORY AGENTS; RESTENOSIS | PFIZER INC. (US) | 1999-01-19 | — | — | US | disclosed |
| US-5750520-A | SELECTIVE THROMBIN INHIBITORS; WOUND HEALING AGENTS | PFIZER INC. (US) | 1998-05-12 | — | — | US | disclosed |
| EP-0728132-B1 | ANTITHROMBOTIC AMIDINOPHENYLALANINE AND AMIDINOPYRIDYLALANINE DERIVATIVES | PFIZER LTD (GB) | 1997-07-16 | — | — | EP | disclosed |
| EP-0728132-A1 | ANTITHROMBOTIC AMIDINOPHENYLALANINE AND AMIDINOPYRIDYLALANINE DERIVATIVES | PFIZER LTD (GB) | 1996-08-28 | — | — | EP | disclosed |
| WO-1995013274-A1 | ANTITHROMBOTIC AMIDINOPHENYLALANINE AND AMIDINOPYRIDYLALANINE DERIVATIVES | PFIZER LIMITED (GB) | 1995-05-18 | — | — | WO | disclosed |