Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TNF | P01375 | 3/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7324461 | 0.88 | TNF (0.37) | KDM4EALOX15TSHRSIRT1PTPN1 | |
| SCHEMBL7331430 | 0.88 | PTPN1 (0.35) | KDM4EALOX15TSHRSIRT1PTPN1 | |
| SCHEMBL7333036 | 0.83 | KDM4E (0.44) | KDM4EALOX15TSHRSIRT1GABRA1 | |
| SCHEMBL7325740 | 0.78 | SIGMAR1 (0.39) | MEN1KMT2ACYP3A4CYP2D6CYP2C19 | |
| SCHEMBL7330449 | 0.77 | TPSAB1 (0.40) | MEN1KMT2AALDH1A1NPSR1CYP3A4 | |
| SCHEMBL7333421 | 0.77 | TPSAB1 (0.40) | MEN1KMT2ANPSR1CYP3A4CYP2D6 | |
| SCHEMBL7327440 | 0.77 | TPSAB1 (0.40) | MEN1KMT2ANPSR1CYP3A4CYP2D6 | |
| SCHEMBL7363847 | 0.77 | CREBBP (0.41) | KDM4EALOX15TSHRSIRT1GABRA1 | |
| SCHEMBL7321392 | 0.75 | TNF (0.38) | KDM4EGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL7133617 | 0.74 | F2 (0.42) | KDM4EALOX15TSHRSIRT1GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5716951-A | PLATELET AGGREGATION INHIBITORS | GENENTECH, INC. (US) | 1998-02-10 | — | — | US | disclosed |
| US-5705890-A | PLATELET AGGREGATION INHIBITOR, ANTITHROMBOTIC | GENENTECH, INC. (US) | 1998-01-06 | — | — | US | disclosed |
| EP-0708775-B1 | TRICYCLIC INHIBITORS OF THE GPII b III a RECEPTOR | GENENTECH INC (US) | 1997-05-28 | — | — | EP | disclosed |
| EP-0708775-A1 | TRICYCLIC INHIBITORS OF THE GPII b III a RECEPTOR | GENENTECH INC (US) | 1996-05-01 | — | — | EP | disclosed |
| US-5493020-A | ANTICOAGULANTS | GENENTECH, INC. (US) | 1996-02-20 | — | — | US | disclosed |
| WO-1995004057-A1 | TRICYCLIC INHIBITORS OF THE GPIIbIIIa RECEPTOR | GENENTECH, INC. (US) | 1995-02-09 | — | — | WO | disclosed |