Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 2/20 | 0.53 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | CASP6 | P55212 | 1/20 | 0.43 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14608039 | 0.81 | MAPT (0.39) | PDCD1CD274KMT2AMAPTMEN1 | |
| SCHEMBL26721829 | 0.79 | KMT2A (0.59) | PDCD1CD274KMT2AMAPTMEN1 | |
| SCHEMBL10435333 | 0.78 | MAPT (0.67) | PDCD1CD274KMT2AMAPTMEN1 | |
| SCHEMBL11182553 | 0.78 | PDCD1 (0.56) | PDCD1CD274KMT2AMAPTMEN1 | |
| SCHEMBL22908674 | 0.75 | KMT2A (0.70) | PDCD1CD274KMT2AMAPTMEN1 | |
| SCHEMBL8616032 | 0.74 | PDCD1 (0.53) | PDCD1CD274KMT2AMAPTMEN1 | |
| SCHEMBL22909309 | 0.74 | KMT2A (0.55) | PDCD1CD274KMT2AMAPTMEN1 | |
| SCHEMBL10435326 | 0.73 | MAPT (0.75) | PDCD1CD274KMT2AMAPTMEN1 | |
| SCHEMBL22908633 | 0.72 | PDCD1 (0.54) | PDCD1CD274KMT2AMAPTMEN1 | |
| SCHEMBL22909301 | 0.72 | KMT2A (0.62) | PDCD1CD274KMT2AMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5750550-A | RESPIRATORY SYSTEM DISORDERS | SANOFI (FR) | 1998-05-12 | — | — | US | disclosed |
| WO-1997010243-A1 | 2-(PYRAZOL-5-YL-OXYMETHYL)-1,2-BENZISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SANOFI (US) | 1997-03-20 | — | — | WO | disclosed |