SCHEMBL7399206

SCHEMBL7399206

O=C(O)C(Cc1ccc2c(c1)OCO2)=C(c1ccc2c(c1)OCO2)c1ccc2c(c1)OCO2

nearest known ligand 0.66

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.66
CYP3A4 P08684 2/20 0.66
CYP1A2 P05177 1/20 0.66
CYP2C19 P33261 1/20 0.66
MAPK1 P28482 1/20 0.57
SRD5A2 P31213 1/20 0.51
CTNNB1 P35222 1/20 0.51
WNT3A P56704 1/20 0.51
NPC1 O15118 2/20 0.50
RAB9A P51151 2/20 0.50
KDM4E B2RXH2 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.50
EDNRB P24530 1/20 0.50
HPGD P15428 2/20 0.49
HSP90AA1 P07900 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7400727 0.92 ALDH1A1 (0.62) ALDH1A1CYP3A4CYP1A2CYP2C19MAPK1
SCHEMBL7404248 0.87 EDNRB (0.61) ALDH1A1CYP3A4CYP1A2CYP2C19NPC1
SCHEMBL109197 0.81 ALDH1A1 (0.64) ALDH1A1CYP3A4CYP1A2CYP2C19MAPK1
Piperonylic Acid SCHEMBL3936749 0.81 ALDH1A1 (0.73) ALDH1A1CYP3A4CYP1A2CYP2C19MAPK1
SCHEMBL31114377 0.80 CYP3A4 (1.00) ALDH1A1CYP3A4CYP1A2CYP2C19MAPK1
SCHEMBL2461730 0.80 CYP3A4 (1.00) ALDH1A1CYP3A4CYP1A2CYP2C19MAPK1
SCHEMBL3944098 0.79 CYP3A4 (0.75) ALDH1A1CYP3A4CYP1A2CYP2C19MAPK1
SCHEMBL138875 0.79 CYP3A4 (0.75) ALDH1A1CYP3A4CYP1A2CYP2C19MAPK1
SCHEMBL29642680 0.79 CYP3A4 (0.75) ALDH1A1CYP3A4CYP1A2CYP2C19MAPK1
SCHEMBL7332204 0.78 CYP3A4 (0.73) ALDH1A1CYP3A4CYP1A2CYP2C19MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0650484-B1 ENDOTHELIN RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORP (US) 2000-01-26 EP claimed
EP-0650484-A1 ENDOTHELIN RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 1995-05-03 EP claimed
WO-1994002474-A1 ENDOTHELIN RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 1994-02-03 WO claimed
EP-0650484-B1 ENDOTHELIN RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORP (US) 2000-01-26 EP disclosed
US-5559105-A ANTAGONIST FOR ENDOTHELIN RECEPTORS, HYPOTENSIVE AGENTS, TREATMENT OF KIDNEY FAILURE OR CEREBROVASCULAR DISORDERS SMITHKLINE BEECHAM CORPORATION (US) 1996-09-24 US disclosed
EP-0650484-A1 ENDOTHELIN RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 1995-05-03 EP disclosed
WO-1994002474-A1 ENDOTHELIN RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 1994-02-03 WO disclosed