SCHEMBL7399266

SCHEMBL7399266

CCOC(=O)CCCCc1c[nH]c2ccccc12

nearest known ligand 0.92

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 4/20 0.92
CYP1A2 P05177 1/20 0.92
CYP3A4 P08684 1/20 0.92
CYP2D6 P10635 1/20 0.92
CYP2C9 P11712 1/20 0.92
CYP2C19 P33261 1/20 0.92
PKM P14618 1/20 0.69
ALDH1A1 P00352 8/20 0.67
CYP4F2 P78329 1/20 0.63
CYP4A11 Q02928 1/20 0.63
KDM4E B2RXH2 3/20 0.61
HPGD P15428 1/20 0.61
TSHR P16473 1/20 0.61
MAPT P10636 6/20 0.61
MEN1 O00255 3/20 0.61
KMT2A Q03164 3/20 0.61
TDP1 Q9NUW8 1/20 0.58
NPC1 O15118 1/20 0.58
LMNA P02545 1/20 0.57
L3MBTL1 Q9Y468 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9374131 0.96 SMN1; SMN2 (1.00) SMN1; SMN2CYP1A2CYP3A4CYP2D6CYP2C9
Hydrochloric Acid SCHEMBL9368572 0.95 SMN1; SMN2 (0.97) SMN1; SMN2CYP1A2CYP3A4CYP2D6CYP2C9
Hydrochloric Acid SCHEMBL9369222 0.95 SMN1; SMN2 (0.97) SMN1; SMN2CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL392573 0.91 SMN1; SMN2 (0.85) SMN1; SMN2CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL9148446 0.86 CYP1A2 (0.70) SMN1; SMN2CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL8978266 0.86 SMN1; SMN2 (0.81) SMN1; SMN2CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL12672577 0.86 MTNR1A (0.78) SMN1; SMN2CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL9152556 0.85 CYP1A2 (0.68) SMN1; SMN2CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL9153271 0.85 SMN1; SMN2 (0.67) SMN1; SMN2CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL7397625 0.84 CYP1A2 (0.73) SMN1; SMN2CYP1A2CYP3A4CYP2D6CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5648368-A ANTICOAGULANTS MERCK & CO., INC. (US) 1997-07-15 US disclosed
EP-0673247-A4 FIBRINOGEN RECEPTOR ANTAGONISTS. MERCK & CO INC (US) 1996-05-01 EP disclosed
EP-0673247-A1 FIBRINOGEN RECEPTOR ANTAGONISTS MERCK & CO. INC. (US) 1995-09-27 EP disclosed
WO-1994012181-A1 FIBRINOGEN RECEPTOR ANTAGONISTS MERCK & CO., INC. (US) 1994-06-09 WO disclosed