Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | PREP | P48147 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21358248 | 0.87 | SMN1; SMN2 (0.37) | SMN1; SMN2NPC1RAB9AHTTPREP | |
| SCHEMBL21360074 | 0.86 | SMN1; SMN2 (0.38) | SMN1; SMN2NPC1RAB9AHTTPREP | |
| SCHEMBL21360073 | 0.86 | SMN1; SMN2 (0.38) | SMN1; SMN2NPC1RAB9AHTTPREP | |
| SCHEMBL21358594 | 0.86 | NPC1 (0.36) | SMN1; SMN2NPC1RAB9AHTTPREP | |
| SCHEMBL31367138 | 0.79 | ELANE (0.48) | SMN1; SMN2NPC1RAB9AHTTPREP | |
| SCHEMBL7399283 | 0.77 | SMN1; SMN2 (0.49) | SMN1; SMN2NPC1RAB9AHTTPREP | |
| SCHEMBL22118726 | 0.76 | TP53 (0.40) | SMN1; SMN2NPC1RAB9AHTTPREP | |
| SCHEMBL31367114 | 0.76 | TP53 (0.40) | SMN1; SMN2NPC1RAB9AHTTPREP | |
| SCHEMBL21367041 | 0.76 | TP53 (0.40) | SMN1; SMN2NPC1RAB9AHTTPREP | |
| SCHEMBL26099378 | 0.76 | MEN1 (0.38) | SMN1; SMN2NPC1RAB9AHTTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12215116-B2 | Arginase inhibitors and methods of use | MERCK SHARP & DOHME LLC (US) | 2025-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12215116-B2 | Arginase inhibitors and methods of use | ARG1, ARG2, PRMT1 | SMN1; SMN2 2527/4885NPC1 516/4885RAB9A 2029/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.