Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.48 |
| ▸ | PLG | P00747 | 1/20 | 0.48 |
| ▸ | PLAU | P00749 | 1/20 | 0.48 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.48 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 3/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.39 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.37 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3017980 | 0.83 | GSK3B (0.53) | GSK3BCA1CA2TSHR | |
| SCHEMBL6490821 | 0.81 | GSK3B (0.56) | GSK3BMEN1KMT2AFFAR1 | |
| SCHEMBL11467826 | 0.81 | AKR1C3 (0.58) | F2PLGPLAUKLKB1PRSS1 | |
| SCHEMBL11471206 | 0.79 | F2 (0.43) | F2PLGPLAUKLKB1PRSS1 | |
| SCHEMBL7469569 | 0.79 | UGT2B7 (0.52) | MEN1KMT2AAKR1C3AKR1C2 | |
| SCHEMBL6839913 | 0.79 | UGT2B7 (0.52) | MEN1KMT2AAKR1C3AKR1C2 | |
| SCHEMBL7440695 | 0.76 | CES2 (0.53) | — | |
| SCHEMBL11778400 | 0.72 | AKR1C3 (0.69) | AKR1C3AKR1C2PTGS2PTGS1CDC42 | |
| SCHEMBL1344485 | 0.72 | CYP2A6 (0.54) | F2PLGPLAUKLKB1PRSS1 | |
| SCHEMBL29489119 | 0.72 | CYP2A6 (0.54) | F2PLGPLAUKLKB1PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177169-A1 | 6- [(ARYL AND HETEROARYL)OXY] METHYL]NAPHTHALENE -2-CARBOXIMIDAMIDE DERIVATIVES, PREPARATION AND THERAPEUTIC APPLICATION THEREOF | SANOFI-SYNTHELABO (FR) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000066545-A1 | 6-[[(ARYL AND HETEROARYL)OXY] METHYL]NAPHTHALENE -2-CARBOXIMIDAMIDE DERIVATIVES, PREPARATION AND THERAPEUTIC APPLICATION THEREOF | SANOFI-SYNTHELABO (FR) | 2000-11-09 | — | — | WO | disclosed |