Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10968126 | 0.70 | HTT (0.47) | KDM4EMAPT | |
| SCHEMBL25153048 | 0.67 | HTT (0.44) | KDM4EMAPT | |
| SCHEMBL10965228 | 0.65 | HTT (0.45) | KDM4EMAPT | |
| SCHEMBL25153046 | 0.64 | HTT (0.44) | KDM4EMAPT | |
| SCHEMBL25158727 | 0.60 | FLT3 (0.36) | — | |
| SCHEMBL3101449 | 0.59 | TDO2 (0.38) | — | |
| SCHEMBL22083942 | 0.59 | KDM4E (0.38) | KDM4E | |
| SCHEMBL31197246 | 0.59 | TDO2 (0.34) | — | |
| SCHEMBL9920397 | 0.57 | HTT (0.34) | KDM4EMAPT | |
| SCHEMBL9920402 | 0.56 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0915877-A1 | SUBSTITUTED TRIAZOLO PYRIDAZINE DERIVATIVES AS INVERSE AGONISTS OF THE GABA A?$g(a)5 RECEPTOR SUBTYPE | MERCK SHARP & DOHME LTD. (GB) | 1999-05-19 | — | — | EP | claimed |
| WO-1998004560-A1 | SUBSTITUTED TRIAZOLO PYRIDAZINE DERIVATIVES AS INVERSE AGONISTS OF THE GABAAα5 RECEPTOR SUBTYPE | MERCK SHARP & DOHME LIMITED (GB) | 1998-02-05 | — | — | WO | claimed |
| US-11083732-B2 | Use of negative modulators of GABA receptors containing alpha5 subunits as fast acting antidepressants | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2021-08-10 | — | — | US | disclosed |
| EP-3125902-B1 | USE OF NEGATIVE MODULATORS OF GABA RECEPTORS CONTAINING ALPHA5 SUBUNITS AS FAST ACTING ANTIDEPRESSANTS | UNIV MARYLAND (US) | 2020-09-16 | — | — | EP | disclosed |
| EP-3125902-A2 | USE OF NEGATIVE MODULATORS OF GABA RECEPTORS CONTAINING ALPHA5 SUBUNITS AS FAST ACTING ANTIDEPRESSANTS | University of Maryland, Baltimore (US) | 2017-02-08 | — | — | EP | disclosed |
| US-20170020892-A1 | USE OF NEGATIVE MODULATORS OF GABA RECEPTORS CONTAINING ALPHA5 SUBUNITS AS FAST ACTING ANTIDEPRESSANTS | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2017-01-26 | — | — | US | disclosed |
| WO-2015153658-A2 | USE OF NEGATIVE MODULATORS OF GABA RECEPTORS CONTAINING ALPHA5 SUBUNITS AS FAST ACTING ANTIDEPRESSANTS | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2015-10-08 | — | — | WO | disclosed |
| EP-0915877-A1 | SUBSTITUTED TRIAZOLO PYRIDAZINE DERIVATIVES AS INVERSE AGONISTS OF THE GABA A?$g(a)5 RECEPTOR SUBTYPE | MERCK SHARP & DOHME LTD. (GB) | 1999-05-19 | — | — | EP | disclosed |
| WO-1998004560-A1 | SUBSTITUTED TRIAZOLO PYRIDAZINE DERIVATIVES AS INVERSE AGONISTS OF THE GABAAα5 RECEPTOR SUBTYPE | MERCK SHARP & DOHME LIMITED (GB) | 1998-02-05 | — | — | WO | disclosed |