Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7393426 | 0.86 | TAAR1 (0.43) | DAOMAOBADORA2AMAPTCYP2C9 | |
| Trifluoroacetic Acid SCHEMBL7399109 | 0.78 | BACE1 (0.42) | DAOMAOBADORA2AMAPTTAAR1 | |
| SCHEMBL7395882 | 0.77 | PTGDR2 (0.45) | DAOTAAR1SIGMAR1AOC3MEN1 | |
| SCHEMBL7398712 | 0.76 | ATM (0.55) | TP53 | |
| SCHEMBL13201398 | 0.75 | KMT2A (0.58) | CYP2C9CYP2C19SIGMAR1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL7390928 | 0.74 | IDO1 (0.45) | MEN1KMT2A | |
| SCHEMBL7396414 | 0.74 | OPRM1 (0.46) | DAOMAOBADORA2ADRD2 | |
| SCHEMBL7396482 | 0.73 | ATM (0.45) | MAOBADORA2AMAPTTP53 | |
| SCHEMBL1116570 | 0.73 | MAOB (0.43) | DAOMAOBADORA2AMAPTCYP2C9 | |
| SCHEMBL7399625 | 0.73 | ATM (0.51) | MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183238-A1 | METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2002-03-06 | — | — | EP | disclosed |
| WO-2000069816-A1 | METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2000-11-23 | — | — | WO | disclosed |