Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7398712 | 0.93 | ATM (0.55) | ATMOPRM1OPRD1CTSLCTSB | |
| SCHEMBL7400701 | 0.87 | LMNA (0.55) | ATMOPRM1OPRD1KMT2ANPC1 | |
| SCHEMBL7396668 | 0.86 | ATM (0.48) | ATMOPRM1OPRD1CTSLCTSB | |
| SCHEMBL7392537 | 0.85 | ATM (0.52) | ATMOPRM1OPRD1CTSLCTSB | |
| SCHEMBL7396482 | 0.84 | ATM (0.45) | ATMOPRM1OPRD1MAPTHDAC1 | |
| SCHEMBL7397699 | 0.83 | ATM (0.43) | ATMOPRM1OPRD1CTSLCTSB | |
| SCHEMBL6141382 | 0.83 | ATM (0.43) | ATMOPRM1OPRD1CTSLCTSB | |
| SCHEMBL7390926 | 0.83 | MEN1 (0.43) | ATMCTSLCTSBCTSSKMT2A | |
| SCHEMBL7396414 | 0.79 | OPRM1 (0.46) | ATMOPRM1OPRD1CTSLL3MBTL1 | |
| SCHEMBL7397676 | 0.78 | ATM (0.53) | ATMKMT2ALMNAALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183238-A1 | METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2002-03-06 | — | — | EP | disclosed |
| WO-2000069816-A1 | METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2000-11-23 | — | — | WO | disclosed |