Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 2/20 | 0.57 |
| ▸ | CCR3 | P51677 | 2/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.57 |
| ▸ | ITGB3 | P05106 | 9/20 | 0.55 |
| ▸ | ITGA2B | P08514 | 9/20 | 0.55 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.45 |
| ▸ | ACACB | O00763 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7332909 | 0.87 | ACACB (0.47) | HRH1CCR3KCNH2ITGB3ITGA2B | |
| SCHEMBL7398480 | 0.85 | ITGB3 (0.53) | HRH1CCR3KCNH2ITGB3ITGA2B | |
| SCHEMBL8633873 | 0.83 | ITGB3 (0.53) | HRH1CCR3KCNH2ITGB3ITGA2B | |
| SCHEMBL7399619 | 0.83 | ITGB3 (0.51) | HRH1CCR3KCNH2ITGB3ITGA2B | |
| SCHEMBL7402069 | 0.80 | ITGB3 (0.53) | ITGB3ITGA2BHRH3 | |
| Hydrochloric Acid SCHEMBL7395390 | 0.80 | ITGB3 (0.53) | HRH1CCR3KCNH2ITGB3ITGA2B | |
| SCHEMBL8601348 | 0.80 | F10 (0.65) | — | |
| SCHEMBL5632393 | 0.80 | NAMPT (0.56) | HRH3ACACB | |
| SCHEMBL7961303 | 0.80 | F10 (0.54) | HRH1FFAR4HRH3ACACB | |
| Hydrochloric Acid SCHEMBL7407623 | 0.79 | ITGB3 (0.53) | ITGB3ITGA2BHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0691959-B1 | HETEROCYCLIC DERIVATIVES AS PLATELET AGGREGATION INHIBITORS | ZENECA LTD (GB) | 1998-07-22 | — | — | EP | disclosed |
| EP-0825184-A1 | Heterocyclic derivatives as platelet aggregation inhibitors | ZENECA LIMITED (GB) | 1998-02-25 | — | — | EP | disclosed |
| US-5652242-A | 3-METHYL-4-(4-(4-(4-PYRIDYL)PIPERAZIN-1-YL)PHENOXY)BURYIC ACID, AMIDE OR ESTER; INHIBITORS OF BINDING OF FIBRINOGEN TO GLYCOPROTEIN | ZENECA LIMITED (GB) | 1997-07-29 | — | — | US | disclosed |
| US-5563141-A | INHIBIT CELL ADHESION FOR EXAMPLE, PLATELET AGGRE GATION | ZENECA LIMITED (GB) | 1996-10-08 | — | — | US | disclosed |
| US-5556977-A | ANTIAGGLOMERANTS FOR CELLS, ANTICOAGULANTS, ANTIISCHEMIC AGENTS USING PYRIDINYLPIPERAZINE DERIVATIVES | ZENECA LIMITED (GB) | 1996-09-17 | — | — | US | disclosed |
| EP-0690847-A1 | HETEROCYCLIC COMPOUNDS AS PLATELET AGGREGATION INHIBITORS | ZENECA LIMITED (GB) | 1996-01-10 | — | — | EP | disclosed |
| WO-1994022835-A2 | HETEROCYCLIC COMPOUNDS AS PLATELET AGGREGATION INHIBITORS | ZENECA LIMITED (GB) | 1994-10-13 | — | — | WO | disclosed |