Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 11/20 | 0.60 |
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | MMP9 | P14780 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6598735 | 0.92 | ADAM17 (0.70) | ADAM17MMP2MMP9 | |
| SCHEMBL7401359 | 0.89 | ADAM17 (0.61) | ADAM17MMP2MMP9 | |
| SCHEMBL7399671 | 0.83 | ADAM17 (0.51) | ADAM17MMP2MMP9 | |
| SCHEMBL6597130 | 0.83 | ADAM17 (0.62) | ADAM17MMP2 | |
| SCHEMBL6595607 | 0.80 | ADAM17 (0.72) | ADAM17MMP2 | |
| SCHEMBL7650602 | 0.77 | ADAM17 (0.62) | ADAM17 | |
| SCHEMBL6741074 | 0.75 | ADAM17 (0.68) | ADAM17 | |
| SCHEMBL6986919 | 0.74 | ADAM17 (0.86) | ADAM17MMP2MMP9 | |
| Trifluoroacetic Acid SCHEMBL6741899 | 0.73 | ADAM17 (0.57) | ADAM17 | |
| SCHEMBL6989061 | 0.73 | ADAM17 (0.59) | ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1263756-A2 | BETA-AMINO ACID DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEASES AND TNF-ALPHA | Bristol-Myers Squibb Pharma Company (US) | 2002-12-11 | — | — | EP | disclosed |
| WO-2001070734-A2 | BETA-AMINO ACID DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEASES AND TNF-ALPHA | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2001-09-27 | — | — | WO | disclosed |