Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 18/20 | 0.55 |
| ▸ | DRD3 | P35462 | 18/20 | 0.55 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.47 |
| ▸ | CHRNG | P07510 | 1/20 | 0.47 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.47 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.47 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.47 |
| ▸ | CHRND | Q07001 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL912111 | 1.00 | DRD2 (0.55) | DRD2DRD3CHRNA1CHRNGCHRNB1 | |
| SCHEMBL990779 | 1.00 | DRD2 (0.55) | DRD2DRD3CHRNA1CHRNGCHRNB1 | |
| Hydrochloric Acid SCHEMBL8690633 | 0.99 | DRD2 (0.54) | DRD2DRD3CHRNA1CHRNGCHRNB1 | |
| Hydrochloric Acid SCHEMBL8904471 | 0.99 | DRD2 (0.54) | DRD2DRD3CHRNA1CHRNGCHRNB1 | |
| SCHEMBL7394942 | 0.89 | DRD2 (0.53) | DRD2DRD3CHRNA1CHRNGCHRNB1 | |
| SCHEMBL11986381 | 0.74 | HTR2C (0.33) | DRD2DRD3 | |
| SCHEMBL8317912 | 0.74 | DRD2 (0.53) | DRD2DRD3CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL6245152 | 0.73 | DRD2 (0.48) | DRD2DRD3CHRNB4CHRNA3 | |
| SCHEMBL7847793 | 0.73 | DRD2 (0.48) | DRD2DRD3CHRNB4CHRNA3 | |
| SCHEMBL29960480 | 0.73 | DRD2 (0.48) | DRD2DRD3CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6365605-B1 | ADMINISTERING D.SUB.3 RECEPTOR LIGAND FOR THERAPY OF CONDITIONS SELECTED FROM DEPRESSION, SCHIZOPHRENIA, PSYCHOSES, PARKINSONS'S DISEASE, MEMORY DISORDERS, AND DISORDERS ASSOCIATED WITH DRUG ABUSE | LES LABORATOIRES SERVIER (FR) | 2002-04-02 | — | — | US | disclosed |
| US-6326377-B1 | PSYCHOLOGICAL DISORDERS THERAPY | ADIR ET COMPAGNIE (FR) | 2001-12-04 | — | — | US | disclosed |
| EP-0887350-B1 | Chromene derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 2001-08-22 | — | — | EP | disclosed |
| US-6090837-A | PSYCHOLOGICAL DISORDERS | ADIR ET COMPAGNIE (FR) | 2000-07-18 | — | — | US | disclosed |
| EP-0691342-B1 | Benzopyran derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1999-04-28 | — | — | EP | disclosed |
| EP-0887350-A1 | Chromene derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1998-12-30 | — | — | EP | disclosed |
| EP-0691342-A1 | Benzopyrane derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-01-10 | — | — | EP | disclosed |