Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 9/20 | 0.64 |
| ▸ | HTR2A | P28223 | 7/20 | 0.64 |
| ▸ | HTR1A | P08908 | 6/20 | 0.64 |
| ▸ | HTR1D | P28221 | 6/20 | 0.64 |
| ▸ | DRD4 | P21917 | 5/20 | 0.64 |
| ▸ | HTR7 | P34969 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | HTR1B | P28222 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7403139 | 0.99 | DRD2 (0.62) | DRD2HTR2AHTR1AHTR1DDRD4 | |
| SCHEMBL7405008 | 0.81 | DRD2 (0.69) | DRD2HTR2AHTR1AHTR1DDRD4 | |
| Hydrochloric Acid SCHEMBL7404051 | 0.80 | DRD2 (0.67) | DRD2HTR2AHTR1AHTR1DDRD4 | |
| SCHEMBL7398695 | 0.80 | DRD2 (0.80) | DRD2HTR2AHTR1AHTR1DDRD4 | |
| SCHEMBL7400103 | 0.79 | MAPK1 (0.55) | HSD17B10 | |
| Hydrochloric Acid SCHEMBL8180020 | 0.79 | DRD2 (0.78) | DRD2HTR2AHTR1AHTR1DDRD4 | |
| SCHEMBL5698958 | 0.78 | DRD2 (1.00) | DRD2HTR2AHTR1AHTR1DDRD4 | |
| SCHEMBL7403377 | 0.77 | DRD2 (0.66) | DRD2HTR2AHTR1AHTR1DDRD4 | |
| Hydrochloric Acid SCHEMBL7400497 | 0.77 | DRD2 (0.98) | DRD2HTR2AHTR1AHTR1DDRD4 | |
| Hydrochloric Acid SCHEMBL7405414 | 0.76 | DRD2 (0.65) | DRD2HTR2AHTR1AHTR1DDRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0737189-B1 | HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF CNS AND CARDIOVASCULAR DISORDERS | UPJOHN CO (US) | 1999-07-28 | — | — | EP | claimed |
| EP-0737189-A1 | HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF CNS AND CARDIOVASCULAR DISORDERS | PHARMACIA & UPJOHN COMPANY (US) | 1996-10-16 | — | — | EP | claimed |
| WO-1995018118-A1 | HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF CNS AND CARDIOVASCULAR DISORDERS | THE UPJOHN COMPANY (US) | 1995-07-06 | — | — | WO | claimed |