SCHEMBL7400103

SCHEMBL7400103

COc1ccc(N2CCN(C(=O)CC3OC(OC)c4ccccc43)CC2)cc1

nearest known ligand 0.55

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 1/20 0.55
MAPT P10636 4/20 0.53
ALDH1A1 P00352 2/20 0.53
LMNA P02545 2/20 0.53
GFER P55789 4/20 0.52
KMT2A Q03164 3/20 0.51
MEN1 O00255 2/20 0.51
HPGD P15428 1/20 0.50
HSD17B10 Q99714 1/20 0.50
PKM P14618 1/20 0.49
CYP2C9 P11712 1/20 0.48
CYP2C19 P33261 1/20 0.48
L3MBTL1 Q9Y468 2/20 0.48
AKR1C3 P42330 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7402692 0.81 MAPK1 (0.55) MAPK1MAPTALDH1A1LMNAGFER
SCHEMBL7399845 0.79 DRD2 (0.64) HSD17B10
Hydrochloric Acid SCHEMBL7403139 0.78 DRD2 (0.62) HSD17B10
SCHEMBL7404596 0.78 DRD2 (0.59) MAPK1MAPTALDH1A1LMNAGFER
SCHEMBL7403392 0.75 MAPK1 (0.56) MAPK1MAPTALDH1A1LMNAGFER
SCHEMBL7398361 0.75 MAPK1 (0.56) MAPK1MAPTALDH1A1LMNAGFER
SCHEMBL7403037 0.74 MAPT (0.48) MAPK1MAPTALDH1A1LMNAGFER
SCHEMBL7397186 0.74 MAPK1 (0.54) MAPK1MAPTALDH1A1LMNAGFER
SCHEMBL12182367 0.72 L3MBTL1 (0.68) MAPK1MAPTALDH1A1LMNAGFER
SCHEMBL20419342 0.72 GFER (0.79) MAPK1MAPTALDH1A1LMNAGFER

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6133446-A Heterocyclic compounds for the treatment of CNS and cardiovascular disorders PHARMACIA & UPJOHN COMPANY (US) 2000-10-17 US disclosed
EP-0737189-B1 HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF CNS AND CARDIOVASCULAR DISORDERS UPJOHN CO (US) 1999-07-28 EP disclosed
EP-0737189-A1 HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF CNS AND CARDIOVASCULAR DISORDERS PHARMACIA & UPJOHN COMPANY (US) 1996-10-16 EP disclosed
WO-1995018118-A1 HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF CNS AND CARDIOVASCULAR DISORDERS THE UPJOHN COMPANY (US) 1995-07-06 WO disclosed