Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | ENPP3 | O14638 | 2/20 | 0.50 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.50 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.48 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.46 |
| ▸ | RORC | P51449 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.44 |
| ▸ | TNF | P01375 | 1/20 | 0.44 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7390354 | 0.92 | PRMT1 (0.51) | NPC1RAB9AMEN1KMT2ARXFP1 | |
| SCHEMBL7397210 | 0.91 | MEN1 (0.56) | NPC1RAB9AENPP3ENPP1ENPP2 | |
| SCHEMBL7394824 | 0.90 | TRPV1 (0.50) | NPC1RAB9ATRPV1MEN1KMT2A | |
| SCHEMBL7390973 | 0.89 | ENPP1 (0.53) | NPC1RAB9AENPP3ENPP1ENPP2 | |
| SCHEMBL7428930 | 0.89 | KMT2A (0.51) | RAB9AMEN1KMT2ALMNAL3MBTL1 | |
| SCHEMBL7397231 | 0.88 | NPC1 (0.53) | NPC1RAB9AMEN1KMT2ALMNA | |
| SCHEMBL7392377 | 0.87 | MEN1 (0.47) | NPC1RAB9AMEN1KMT2ARXFP1 | |
| SCHEMBL7393966 | 0.84 | KCNQ3 (0.51) | NPC1RAB9AMEN1KMT2ALMNA | |
| SCHEMBL7394728 | 0.84 | MAPT (0.54) | NPC1RAB9AMEN1KMT2ALMNA | |
| SCHEMBL7396365 | 0.82 | NPC1 (0.51) | NPC1RAB9AENPP3ENPP1ENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002006215-A1 | 3-ARYLSULFONYL-2-HYDROXY-2-METHYLPROPANOIC ACID DERIVATES | PHARMACIA ITALIA S.P.A. (IT) | 2002-01-24 | — | — | WO | disclosed |