Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | TRPV4 | Q9HBA0 | 5/20 | 0.48 |
| ▸ | ENPP3 | O14638 | 2/20 | 0.46 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.46 |
| ▸ | RORC | P51449 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.43 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7394539 | 0.91 | KMT2A (0.50) | NPC1RAB9AKMT2AMEN1KDM4E | |
| SCHEMBL7394619 | 0.89 | PRMT1 (0.52) | NPC1ENPP3ENPP1KMT2AMEN1 | |
| SCHEMBL7398968 | 0.89 | PRMT1 (0.52) | NPC1ENPP3ENPP1KMT2AMEN1 | |
| SCHEMBL7395666 | 0.89 | NAMPT (0.49) | RAB9AKMT2AMEN1KDM4EPOLB | |
| SCHEMBL7396547 | 0.89 | TRPV1 (0.48) | NPC1RAB9AKMT2AMEN1KDM4E | |
| SCHEMBL7493288 | 0.86 | RAB9A (0.51) | NPC1RAB9AKMT2AMEN1KDM4E | |
| SCHEMBL7396188 | 0.83 | NPC1 (0.46) | NPC1RAB9AKMT2AMEN1POLB | |
| SCHEMBL7388689 | 0.82 | ENPP1 (0.51) | NPC1RAB9AENPP3ENPP1KMT2A | |
| SCHEMBL7399956 | 0.82 | NPC1 (0.51) | NPC1RAB9ATRPV4ENPP3ENPP1 | |
| SCHEMBL7438033 | 0.81 | RAB9A (0.54) | NPC1RAB9AKMT2AMEN1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002006215-A1 | 3-ARYLSULFONYL-2-HYDROXY-2-METHYLPROPANOIC ACID DERIVATES | PHARMACIA ITALIA S.P.A. (IT) | 2002-01-24 | — | — | WO | claimed |
| WO-2002006215-A1 | 3-ARYLSULFONYL-2-HYDROXY-2-METHYLPROPANOIC ACID DERIVATES | PHARMACIA ITALIA S.P.A. (IT) | 2002-01-24 | — | — | WO | disclosed |