Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 3/20 | 0.36 |
| ▸ | KDM2B | Q8NHM5 | 6/20 | 0.35 |
| ▸ | DRD3 | P35462 | 2/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD1 | P21728 | 1/20 | 0.33 |
| ▸ | DRD5 | P21918 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL7400346 | 1.00 | DRD4 (0.36) | DRD4KDM2BDRD3HRH3DRD2 | |
| Oxalic Acid SCHEMBL7401971 | 0.89 | KDM2B (0.44) | KDM2BDRD2 | |
| Oxalic Acid SCHEMBL7401973 | 0.89 | KDM2B (0.44) | KDM2BDRD2 | |
| Oxalic Acid SCHEMBL7402350 | 0.88 | KDM4E (0.39) | KDM2B | |
| Oxalic Acid SCHEMBL467153 | 0.69 | DRD4 (0.40) | DRD4HRH3 | |
| Oxalic Acid SCHEMBL467154 | 0.69 | DRD4 (0.40) | DRD4HRH3 | |
| Oxalic Acid SCHEMBL7367006 | 0.68 | SMN1; SMN2 (0.32) | DRD4 | |
| SCHEMBL5449384 | 0.65 | ATM (0.54) | DRD4 | |
| SCHEMBL14604957 | 0.65 | ATM (0.54) | DRD4 | |
| SCHEMBL5449388 | 0.65 | ATM (0.54) | DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993019047-A1 | TETRAHIDROPYRIDINYL (3/4) SUBSTITUED OXIMES HAVING SIGMA RECEPTOR AFFINITY AND THEIR USE IN THE TREATMENT OF CENTRAL NERVOUS SYSTEM CONDITIONS | WARNER-LAMBERT COMPANY (US) | 1993-09-30 | — | — | WO | disclosed |
| US-5208343-A | Antidepressants, antiinflammatory | WARNER-LAMBERT COMPANY (US) | 1993-05-04 | — | — | US | disclosed |