Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM2B | Q8NHM5 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL7401973 | 1.00 | KDM2B (0.44) | KDM2BKMT2AALDH1A1GAAMEN1 | |
| Oxalic Acid SCHEMBL7402348 | 0.91 | KDM4E (0.39) | KDM2BKMT2AALDH1A1KDM4EMAPT | |
| Oxalic Acid SCHEMBL7402350 | 0.91 | KDM4E (0.39) | KDM2BKMT2AALDH1A1KDM4EMAPT | |
| Oxalic Acid SCHEMBL7400341 | 0.89 | DRD4 (0.36) | KDM2BDRD2 | |
| Oxalic Acid SCHEMBL7400346 | 0.89 | DRD4 (0.36) | KDM2BDRD2 | |
| SCHEMBL9476248 | 0.77 | KDM2B (0.41) | KDM2BKMT2AALDH1A1GAAMEN1 | |
| Oxalic Acid SCHEMBL7396176 | 0.72 | KDM2B (0.43) | KDM2BKMT2AALDH1A1GAAMEN1 | |
| Oxalic Acid SCHEMBL7396173 | 0.72 | KDM2B (0.43) | KDM2BKMT2AALDH1A1GAAMEN1 | |
| Oxalic Acid SCHEMBL7367356 | 0.71 | SMN1; SMN2 (0.38) | KDM2BKMT2AALDH1A1GAAKDM4E | |
| SCHEMBL13268902 | 0.67 | SMN1; SMN2 (0.64) | KMT2AALDH1A1GAAMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5208343-A | Antidepressants, antiinflammatory | WARNER-LAMBERT COMPANY (US) | 1993-05-04 | — | — | US | claimed |
| WO-1993019047-A1 | TETRAHIDROPYRIDINYL (3/4) SUBSTITUED OXIMES HAVING SIGMA RECEPTOR AFFINITY AND THEIR USE IN THE TREATMENT OF CENTRAL NERVOUS SYSTEM CONDITIONS | WARNER-LAMBERT COMPANY (US) | 1993-09-30 | — | — | WO | disclosed |
| US-5208343-A | Antidepressants, antiinflammatory | WARNER-LAMBERT COMPANY (US) | 1993-05-04 | — | — | US | disclosed |