Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | MAPT | P10636 | 3/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | NSD2 | O96028 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | CES2 | O00748 | 1/20 | 0.31 |
| ▸ | CES1 | P23141 | 1/20 | 0.31 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.30 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
| ▸ | DRD4 | P21917 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL7367356 | 0.89 | SMN1; SMN2 (0.38) | SMN1; SMN2KMT2AALDH1A1GAAHTT | |
| Oxalic Acid SCHEMBL7400346 | 0.68 | DRD4 (0.36) | DRD4 | |
| Oxalic Acid SCHEMBL7362316 | 0.68 | SMN1; SMN2 (0.31) | SMN1; SMN2KMT2AALDH1A1MAPTHTT | |
| Oxalic Acid SCHEMBL7400341 | 0.68 | DRD4 (0.36) | DRD4 | |
| SCHEMBL5449388 | 0.65 | ATM (0.54) | SMN1; SMN2KMT2AALDH1A1MAPTMEN1 | |
| SCHEMBL14604957 | 0.65 | ATM (0.54) | SMN1; SMN2KMT2AALDH1A1MAPTMEN1 | |
| SCHEMBL5449384 | 0.65 | ATM (0.54) | SMN1; SMN2KMT2AALDH1A1MAPTMEN1 | |
| SCHEMBL5450434 | 0.63 | PTGS2 (0.53) | SMN1; SMN2KMT2AALDH1A1MAPTMEN1 | |
| SCHEMBL5450436 | 0.63 | PTGS2 (0.53) | SMN1; SMN2KMT2AALDH1A1MAPTMEN1 | |
| SCHEMBL27348181 | 0.61 | KDM4E (0.57) | SMN1; SMN2KMT2AMAPTMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993019047-A1 | TETRAHIDROPYRIDINYL (3/4) SUBSTITUED OXIMES HAVING SIGMA RECEPTOR AFFINITY AND THEIR USE IN THE TREATMENT OF CENTRAL NERVOUS SYSTEM CONDITIONS | WARNER-LAMBERT COMPANY (US) | 1993-09-30 | — | — | WO | claimed |
| WO-1993019047-A1 | TETRAHIDROPYRIDINYL (3/4) SUBSTITUED OXIMES HAVING SIGMA RECEPTOR AFFINITY AND THEIR USE IN THE TREATMENT OF CENTRAL NERVOUS SYSTEM CONDITIONS | WARNER-LAMBERT COMPANY (US) | 1993-09-30 | — | — | WO | disclosed |