SCHEMBL7400463

SCHEMBL7400463

Cc1ccc(S(=O)(=O)Nc2ccc(N)c(C(C)C)c2)cc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FFAR4 Q5NUL3 1/20 0.61
PTPRC P08575 1/20 0.53
ALDH1A1 P00352 6/20 0.51
LMNA P02545 5/20 0.51
SMN1; SMN2 Q16637 2/20 0.51
GAA P10253 2/20 0.51
THRB P10828 1/20 0.51
L3MBTL1 Q9Y468 1/20 0.51
MAPT P10636 4/20 0.51
USP2 O75604 1/20 0.51
HTT P42858 1/20 0.51
HSD17B10 Q99714 1/20 0.51
CA12 O43570 1/20 0.50
CA1 P00915 1/20 0.50
CA2 P00918 1/20 0.50
CA9 Q16790 1/20 0.50
ESR1 P03372 1/20 0.49
CYP19A1 P11511 1/20 0.49
MEN1 O00255 2/20 0.49
KMT2A Q03164 2/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7402012 0.83 ALDH1A1 (0.52) FFAR4PTPRCALDH1A1LMNASMN1; SMN2
SCHEMBL14403378 0.82 ALDH1A1 (0.60) FFAR4PTPRCALDH1A1LMNASMN1; SMN2
SCHEMBL28790906 0.82 FFAR4 (0.68) FFAR4PTPRCALDH1A1LMNASMN1; SMN2
SCHEMBL7404768 0.80 FFAR4 (0.57) FFAR4PTPRCALDH1A1LMNASMN1; SMN2
SCHEMBL17102990 0.79 FFAR4 (0.63) FFAR4PTPRCALDH1A1LMNASMN1; SMN2
Oxalic Acid SCHEMBL7965054 0.78 ALDH1A1 (0.50) FFAR4PTPRCALDH1A1LMNASMN1; SMN2
SCHEMBL2434886 0.78 GAA (0.55) FFAR4ALDH1A1LMNASMN1; SMN2GAA
SCHEMBL1415291 0.77 TRIM24 (0.58) FFAR4ALDH1A1LMNASMN1; SMN2GAA
SCHEMBL28543669 0.76 FFAR4 (1.00) FFAR4ALDH1A1LMNASMN1; SMN2THRB
SCHEMBL6151524 0.76 FFAR4 (0.78) FFAR4PTPRCALDH1A1LMNASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1072210-C 1-phenyl-3-pyrazolecarboxamides active on neurotensin receptors SANOFI SYNTHELABO (FR) 2001-10-03 CN disclosed
EP-1097921-A1 Phenylhydrazines SANOFI-SYNTHELABO (FR) 2001-05-09 EP disclosed
US-6172239-B1 PSYCHOLOGICAL, NERVOUS SYSTEM DISORDERS SANOFI (FR) 2001-01-09 US disclosed
US-5965579-A ANTAGONISTS OF THE NEUROTENSIN RECEPTORS; INCREASING AFFINITY FOR HUMAN NEUROTENSIN RECEPTORS SANOFI (FR) 1999-10-12 US disclosed
US-5939449-A NOVEL COMPOUNDS HAVING HIGH AFFINITY FOR THE NEUROTENSIN RECEPTORS SANOFI (FR) 1999-08-17 US disclosed
US-5936123-A COMPOUNDS SUCH AS 3-ISOPROPYL-4-HYDRAZINOBENZOIC ACID AND ITS SALTS SANOFI (FR) 1999-08-10 US disclosed
US-5925661-A NERVOUS SYSTEM DISORDERS SANOFI (FR) 1999-07-20 US disclosed
CN-1184469-A 1-phenyl-3-pyrazolecarboxamides active on neurotensin receptors SANOFI SA (FR) 1998-06-10 CN disclosed
US-5723483-A NEUROTENSIN ANTAGONIST, HYPOTENSIVE AGENTS AND FOR NEUROPSYCHIATRIC DISORDERS SANOFI (FR) 1998-03-03 US disclosed
EP-0820444-A1 1-PHENYLPYRAZOLE-3-CARBOXAMIDES ACTING ON NEUROTENSIN RECEPTORS SANOFI (FR) 1998-01-28 EP disclosed
WO-1996032382-A1 1-PHENYLPYRAZOLE-3-CARBOXAMIDES ACTING ON NEUROTENSIN RECEPTORS SANOFI (FR) 1996-10-17 WO disclosed