Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 8/20 | 0.70 |
| ▸ | MMP2 | P08253 | 1/20 | 0.68 |
| ▸ | MMP13 | P45452 | 1/20 | 0.68 |
| ▸ | MMP12 | P39900 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6596502 | 0.93 | ADAM17 (0.72) | ADAM17MMP2MMP13MMP12 | |
| SCHEMBL6597920 | 0.86 | ADAM17 (0.64) | ADAM17MMP2MMP13MMP12 | |
| SCHEMBL7404746 | 0.85 | ADAM17 (0.62) | ADAM17MMP2MMP13MMP12 | |
| SCHEMBL7400895 | 0.85 | ADAM17 (0.67) | ADAM17MMP2MMP13MMP12 | |
| SCHEMBL7400564 | 0.84 | ADAM17 (0.70) | ADAM17MMP2MMP13MMP12 | |
| SCHEMBL6598171 | 0.84 | ADAM17 (0.71) | ADAM17MMP2MMP13MMP12 | |
| SCHEMBL6600428 | 0.82 | ADAM17 (1.00) | ADAM17MMP13 | |
| SCHEMBL6595325 | 0.81 | ADAM17 (0.74) | ADAM17MMP2MMP13MMP12 | |
| SCHEMBL7404748 | 0.81 | ADAM17 (0.54) | ADAM17MMP2MMP13MMP12 | |
| SCHEMBL6595866 | 0.80 | ADAM17 (0.64) | ADAM17MMP2MMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1263756-A2 | BETA-AMINO ACID DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEASES AND TNF-ALPHA | Bristol-Myers Squibb Pharma Company (US) | 2002-12-11 | — | — | EP | disclosed |
| WO-2001070734-A2 | BETA-AMINO ACID DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEASES AND TNF-ALPHA | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2001-09-27 | — | — | WO | disclosed |