Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.47 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.47 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.43 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | MARK3 | P27448 | 1/20 | 0.41 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.41 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.41 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.41 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.41 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.41 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.41 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.41 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17530499 | 1.00 | CHRNA7 (0.47) | CHRNA7CHRNA10CHRNA9GPR119ACVR1 | |
| SCHEMBL19057096 | 0.86 | CHRNA7 (0.42) | CHRNA7CHRNA10CHRNA9GPR119ACVR1 | |
| SCHEMBL1665710 | 0.85 | USP2 (0.58) | USP2FGFR1NTRK1RETPDGFRB | |
| SCHEMBL4435359 | 0.85 | USP2 (0.58) | USP2FGFR1NTRK1RETPDGFRB | |
| SCHEMBL24115187 | 0.85 | NPC1 (0.51) | GPR119USP2FGFR1NTRK1RET | |
| SCHEMBL8183599 | 0.83 | ACVR1 (0.48) | CHRNA7CHRNA10CHRNA9GPR119ACVR1 | |
| SCHEMBL64018 | 0.81 | ALDH1A1 (0.57) | FGFR1NTRK1RETPDGFRBMARK3 | |
| SCHEMBL2771145 | 0.80 | MAPT (0.53) | CHRNA7CHRNA10CHRNA9GPR119ACVR1 | |
| SCHEMBL25629582 | 0.79 | CHRNA7 (0.47) | CHRNA7CHRNA10CHRNA9GPR119ACVR1 | |
| Hydrochloric Acid SCHEMBL16210291 | 0.79 | MAPT (0.51) | CHRNA7CHRNA10CHRNA9GPR119ACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6133446-A | Heterocyclic compounds for the treatment of CNS and cardiovascular disorders | PHARMACIA & UPJOHN COMPANY (US) | 2000-10-17 | — | — | US | disclosed |
| EP-0737189-B1 | HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF CNS AND CARDIOVASCULAR DISORDERS | UPJOHN CO (US) | 1999-07-28 | — | — | EP | disclosed |
| EP-0737189-A1 | HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF CNS AND CARDIOVASCULAR DISORDERS | PHARMACIA & UPJOHN COMPANY (US) | 1996-10-16 | — | — | EP | disclosed |
| WO-1995018118-A1 | HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF CNS AND CARDIOVASCULAR DISORDERS | THE UPJOHN COMPANY (US) | 1995-07-06 | — | — | WO | disclosed |