⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7265308 | 0.80 | — | — | |
| SCHEMBL5682960 | 0.65 | KDM4E (0.33) | — | |
| SCHEMBL7748938 | 0.65 | — | — | |
| SCHEMBL33719 | 0.64 | — | — | |
| SCHEMBL125608 | 0.64 | — | — | |
| SCHEMBL1358070 | 0.64 | — | — | |
| SCHEMBL930987 | 0.63 | — | — | |
| SCHEMBL2432721 | 0.63 | — | — | |
| SCHEMBL7273232 | 0.62 | — | — | |
| SCHEMBL931261 | 0.62 | CYP3A4 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6043263-A | (2,3-dihydrobenzofuranyl)-thiazoles as phosphodiesterase inhibitors | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 2000-03-28 | — | — | US | disclosed |
| EP-0941226-A1 | (2,3-DIHYDROBENZOFURANYL)-THIAZOLES AS PHOSPHODIESTERASE INHIBITORS | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1999-09-15 | — | — | EP | disclosed |
| WO-1998021207-A1 | (2,3-DIHYDROBENZOFURANYL)-THIAZOLES AS PHOSPHODIESTERASE INHIBITORS | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1998-05-22 | — | — | WO | disclosed |
| WO-1998008844-A1 | THIAZOLE DERIVATIVES USEFUL AS SELECTIVE INHIBITORS OF PDE-IV | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1998-03-05 | — | — | WO | disclosed |