Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR3 | P29371 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | CCR3 | P51677 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MGLL | Q99685 | 1/20 | 0.51 |
| ▸ | TACR1 | P25103 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | FAAH | O00519 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23682656 | 0.81 | TACR3 (0.83) | TACR3ALDH1A1TP53HSD17B10RAB9A | |
| SCHEMBL29025202 | 0.80 | DPP4 (0.46) | ALDH1A1TP53MEN1KMT2AKDM4E | |
| SCHEMBL8433797 | 0.79 | GAA (0.51) | TACR3ALDH1A1TP53HSD17B10RAB9A | |
| SCHEMBL16002994 | 0.79 | SYK (0.47) | ALDH1A1KDM4E | |
| SCHEMBL13826434 | 0.77 | SYK (0.46) | ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL9785880 | 0.76 | TACR3 (0.57) | TACR3ALDH1A1TP53HSD17B10RAB9A | |
| SCHEMBL2243090 | 0.74 | ALDH1A1 (0.64) | TACR3ALDH1A1RAB9AMEN1KMT2A | |
| SCHEMBL8904897 | 0.74 | ALDH1A1 (0.64) | TACR3ALDH1A1RAB9AMEN1KMT2A | |
| SCHEMBL7362106 | 0.74 | ALDH1A1 (0.64) | TACR3ALDH1A1RAB9AMEN1KMT2A | |
| SCHEMBL6485095 | 0.74 | ALDH1A1 (0.64) | TACR3ALDH1A1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0960102-A1 | AMIDINOINDOLES, AMIDINOAZOLES, AND ANALOGS THEREOF AS INHIBITORS OF FACTOR Xa AND OF THROMBIN | Du Pont Pharmaceuticals Company (US) | 1999-12-01 | — | — | EP | disclosed |
| WO-1998001428-A1 | AMIDINOINDOLES, AMIDINOAZOLES, AND ANALOGS THEREOF AS INHIBITORS OF FACTOR Xa AND OF THROMBIN | DU PONT PHARMACEUTICALS COMPANY (US) | 1998-01-15 | — | — | WO | disclosed |