Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 8/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | ADAMTS4 | O75173 | 3/20 | 0.52 |
| ▸ | MMP3 | P08254 | 3/20 | 0.52 |
| ▸ | ADAMTS1 | Q9UHI8 | 3/20 | 0.52 |
| ▸ | ADAMTS5 | Q9UNA0 | 3/20 | 0.52 |
| ▸ | MMP7 | P09237 | 2/20 | 0.52 |
| ▸ | MMP8 | P22894 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.51 |
| ▸ | MMP1 | P03956 | 1/20 | 0.51 |
| ▸ | MMP10 | P09238 | 1/20 | 0.51 |
| ▸ | MMP14 | P50281 | 1/20 | 0.51 |
| ▸ | MMP15 | P51511 | 1/20 | 0.51 |
| ▸ | MMP2 | P08253 | 1/20 | 0.50 |
| ▸ | MMP12 | P39900 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6598359 | 0.90 | ADAM17 (0.70) | ADAM17ADAMTS4MMP3ADAMTS1ADAMTS5 | |
| SCHEMBL7402595 | 0.83 | ADAM17 (0.63) | ADAM17SMN1; SMN2MMP3ADAM10MMP1 | |
| SCHEMBL7404997 | 0.82 | SMN1; SMN2 (0.54) | ADAM17SMN1; SMN2ADAM10MMP1 | |
| SCHEMBL7404234 | 0.82 | ADAM17 (0.55) | ADAM17ADAM10MMP1MMP2 | |
| SCHEMBL7404737 | 0.81 | ADAM17 (0.53) | ADAM17SMN1; SMN2ADAMTS4MMP3ADAMTS1 | |
| SCHEMBL7407612 | 0.81 | ADAM17 (0.51) | ADAM17SMN1; SMN2ADAMTS4MMP3ADAMTS1 | |
| SCHEMBL6629881 | 0.81 | SMN1; SMN2 (0.55) | ADAM17SMN1; SMN2HTTPKMMMP2 | |
| SCHEMBL1504768 | 0.81 | ADAM17 (0.64) | ADAM17SMN1; SMN2MMP3ADAM10MMP1 | |
| SCHEMBL7403677 | 0.81 | ADAM17 (0.61) | ADAM17SMN1; SMN2MMP3ADAM10MMP1 | |
| SCHEMBL7400907 | 0.80 | SMN1; SMN2 (0.53) | ADAM17SMN1; SMN2ADAMTS4MMP3ADAMTS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1263756-A2 | BETA-AMINO ACID DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEASES AND TNF-ALPHA | Bristol-Myers Squibb Pharma Company (US) | 2002-12-11 | — | — | EP | disclosed |
| WO-2001070734-A2 | BETA-AMINO ACID DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEASES AND TNF-ALPHA | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2001-09-27 | — | — | WO | disclosed |