Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | ADAM17 | P78536 | 8/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.45 |
| ▸ | MMP1 | P03956 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.45 |
| ▸ | GCG | P01275 | 1/20 | 0.44 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.44 |
| ▸ | MMP3 | P08254 | 2/20 | 0.44 |
| ▸ | MMP7 | P09237 | 2/20 | 0.44 |
| ▸ | ADAMTS1 | Q9UHI8 | 2/20 | 0.44 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7402599 | 0.85 | ADAM17 (0.55) | SMN1; SMN2ADAM17MEN1KMT2AKDM4E | |
| SCHEMBL7405002 | 0.83 | SMN1; SMN2 (0.51) | SMN1; SMN2ADAM17MEN1KMT2AKDM4E | |
| SCHEMBL7403682 | 0.83 | ADAM17 (0.53) | SMN1; SMN2ADAM17MEN1KMT2AKDM4E | |
| SCHEMBL7404740 | 0.82 | SMN1; SMN2 (0.50) | SMN1; SMN2ADAM17ADAM10MMP1MMP2 | |
| SCHEMBL6598359 | 0.82 | ADAM17 (0.70) | ADAM17ADAM10MMP1MMP2ADAMTS4 | |
| SCHEMBL7403617 | 0.81 | SMN1; SMN2 (0.44) | SMN1; SMN2ADAM17KDM4EADAMTS4MMP3 | |
| SCHEMBL6629887 | 0.80 | SMN1; SMN2 (0.49) | SMN1; SMN2MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL7402889 | 0.80 | MMP2 (0.44) | ADAM17MMP2 | |
| SCHEMBL7400903 | 0.80 | ADAM17 (0.58) | SMN1; SMN2ADAM17ADAM10MMP1MMP2 | |
| SCHEMBL7407963 | 0.80 | ADAM17 (0.48) | SMN1; SMN2ADAM17ADAM10MMP1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1263756-A2 | BETA-AMINO ACID DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEASES AND TNF-ALPHA | Bristol-Myers Squibb Pharma Company (US) | 2002-12-11 | — | — | EP | disclosed |
| WO-2001070734-A2 | BETA-AMINO ACID DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEASES AND TNF-ALPHA | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2001-09-27 | — | — | WO | disclosed |