Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.64 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.60 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.59 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | VNN1 | O95497 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17600741 | 0.88 | SPHK2 (0.59) | NAMPTHCRTR1HCRTR2POLBNPC1 | |
| SCHEMBL17600738 | 0.88 | SPHK2 (0.59) | NAMPTHCRTR1HCRTR2POLBNPC1 | |
| SCHEMBL17850446 | 0.86 | NAMPT (0.58) | NAMPTAKR1C3POLBTP53NPC1 | |
| SCHEMBL20609497 | 0.86 | TP53 (0.69) | NAMPTHCRTR1HCRTR2POLBTP53 | |
| SCHEMBL13965438 | 0.84 | HCRTR1 (0.51) | NAMPTHCRTR1HCRTR2TP53GAA | |
| SCHEMBL31106406 | 0.84 | NPC1 (0.60) | HCRTR1HCRTR2NPC1GAAHPGD | |
| SCHEMBL11447207 | 0.83 | SPHK2 (0.64) | HCRTR1HCRTR2POLBNPC1VNN1 | |
| SCHEMBL4931440 | 0.83 | SPHK2 (0.64) | HCRTR1HCRTR2POLBNPC1VNN1 | |
| SCHEMBL15317709 | 0.82 | NAMPT (0.55) | NAMPTAKR1C3POLBNPC1GAA | |
| SCHEMBL17570419 | 0.82 | HRH3 (0.59) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0711162-A4 | IMIDAZOLE 5-POSITION SUBSTITUTED ANGIOTENSIN II ANTAGONISTS | DU PONT MERCK PHARMA (US) | 1996-09-04 | — | — | EP | disclosed |
| US-5545651-A | HYPOTENSIVE AGENTS | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-08-13 | — | — | US | disclosed |
| EP-0711162-A1 | IMIDAZOLE 5-POSITION SUBSTITUTED ANGIOTENSIN II ANTAGONISTS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-05-15 | — | — | EP | disclosed |
| US-5395844-A | Hypotensive agents; congestive heart failure | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1995-03-07 | — | — | US | disclosed |
| WO-1994028896-A1 | IMIDAZOLE 5-POSITION SUBSTITUTED ANGIOTENSIN II ANTAGONISTS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1994-12-22 | — | — | WO | disclosed |