Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SNCA | P37840 | 2/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4798754 | 0.81 | ALDH1A1 (0.36) | KDM4EALDH1A1MEN1KMT2ASLC6A4 | |
| SCHEMBL872381 | 0.79 | ALDH1A1 (0.49) | KDM4EALDH1A1MEN1NPC1KMT2A | |
| SCHEMBL25343452 | 0.78 | RAD51 (0.39) | KDM4EALDH1A1CYP1A2CYP3A4GAA | |
| SCHEMBL6823718 | 0.76 | NTRK1 (0.40) | SNCAGRM2SIGMAR1TMEM97KDM4E | |
| SCHEMBL153227 | 0.71 | MEN1 (0.51) | SNCASIGMAR1TMEM97ALDH1A1MEN1 | |
| SCHEMBL7392195 | 0.70 | SLC6A4 (0.41) | SNCAGRM2SIGMAR1TMEM97NR3C1 | |
| SCHEMBL3932203 | 0.69 | MAOB (0.54) | NPC1RAB9A | |
| SCHEMBL7393592 | 0.69 | MAOA (0.53) | ALDH1A1POLBLMNANPSR1CYP1A2 | |
| SCHEMBL10687666 | 0.69 | IP6K1 (0.50) | KDM4EALDH1A1MEN1NPC1KMT2A | |
| SCHEMBL7397510 | 0.69 | MAOB (0.54) | ALDH1A1LMNACCNCCDK8GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5863947-A | Phenylglycine derivatives useful for treating disorders of the central nervous system | ELI LILLY AND COMPANY LIMITED (GB) | 1999-01-26 | — | — | US | disclosed |
| EP-0807621-A1 | Derivatives of phenylglycine and use thereof as pharmaceuticals | LILLY INDUSTRIES LIMITED (GB) | 1997-11-19 | — | — | EP | disclosed |