Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.64 |
| ▸ | HPGD | P15428 | 3/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.64 |
| ▸ | HTT | P42858 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | LMNA | P02545 | 5/20 | 0.47 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7363630 | 0.95 | ALDH1A1 (0.70) | ALDH1A1HPGDSMN1; SMN2HTTMAPT | |
| SCHEMBL15941304 | 0.88 | ALDH1A1 (0.62) | ALDH1A1HPGDSMN1; SMN2HTTMAPT | |
| SCHEMBL9247222 | 0.88 | ALDH1A1 (0.62) | ALDH1A1HPGDSMN1; SMN2HTTMAPT | |
| SCHEMBL7358847 | 0.86 | ALDH1A1 (0.61) | ALDH1A1HPGDSMN1; SMN2HTTMAPT | |
| SCHEMBL7926214 | 0.85 | ALDH1A1 (0.88) | ALDH1A1HPGDSMN1; SMN2HTTMAPT | |
| SCHEMBL7927335 | 0.85 | ALDH1A1 (0.88) | ALDH1A1HPGDSMN1; SMN2HTTMAPT | |
| SCHEMBL6914412 | 0.80 | ALDH1A1 (1.00) | ALDH1A1HPGDSMN1; SMN2HTTMAPT | |
| SCHEMBL31371989 | 0.79 | ALDH1A1 (0.75) | ALDH1A1HPGDSMN1; SMN2HTTMAPT | |
| SCHEMBL28473484 | 0.78 | ALDH1A1 (0.72) | ALDH1A1HPGDSMN1; SMN2HTTMAPT | |
| SCHEMBL28874055 | 0.78 | ALDH1A1 (0.72) | ALDH1A1HPGDSMN1; SMN2HTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5378718-A | Cardiovascular activity, hypotensive | CEDONA PHARMACEUTICALS B.V. (NL) | 1995-01-03 | — | — | US | disclosed |
| WO-1992002503-A1 | NOVEL 1,4-DIHYDROPYRIDINE DERIVATIVES | CEDONA PHARMACEUTICALS BV (NL) | 1992-02-20 | — | — | WO | disclosed |