SCHEMBL7363630

SCHEMBL7363630

O=Cc1ccccc1OCCO[N+](=O)[O-]

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 8/20 0.70
SMN1; SMN2 Q16637 3/20 0.70
HPGD P15428 2/20 0.70
HTT P42858 1/20 0.70
MAPT P10636 5/20 0.64
NPC1 O15118 3/20 0.50
RAB9A P51151 3/20 0.50
RECQL P46063 2/20 0.50
PTGDR2 Q9Y5Y4 1/20 0.50
KMT2A Q03164 5/20 0.43
MEN1 O00255 2/20 0.43
LMNA P02545 3/20 0.43
GAA P10253 1/20 0.43
SRC P12931 1/20 0.41
PTGS2 P35354 1/20 0.41
L3MBTL1 Q9Y468 2/20 0.40
KDM4E B2RXH2 1/20 0.40
POLB P06746 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
RAD52 P43351 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7401225 0.95 ALDH1A1 (0.64) ALDH1A1SMN1; SMN2HPGDHTTMAPT
SCHEMBL9247222 0.92 ALDH1A1 (0.62) ALDH1A1SMN1; SMN2HPGDHTTMAPT
SCHEMBL15941304 0.92 ALDH1A1 (0.62) ALDH1A1SMN1; SMN2HPGDHTTMAPT
SCHEMBL7358847 0.90 ALDH1A1 (0.61) ALDH1A1SMN1; SMN2HPGDHTTMAPT
SCHEMBL6914412 0.84 ALDH1A1 (1.00) ALDH1A1SMN1; SMN2HPGDHTTMAPT
SCHEMBL9148490 0.81 NPC1 (0.53) ALDH1A1SMN1; SMN2HPGDHTTMAPT
SCHEMBL2762935 0.80 ALDH1A1 (0.47) ALDH1A1SMN1; SMN2HPGDHTTMAPT
SCHEMBL7362094 0.80 ALDH1A1 (0.44) ALDH1A1SMN1; SMN2HPGDHTTMAPT
SCHEMBL9152090 0.80 PTGDR2 (0.51) ALDH1A1SMN1; SMN2HPGDHTTMAPT
SCHEMBL1765172 0.79 ALDH1A1 (0.63) ALDH1A1SMN1; SMN2HPGDHTTMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0740649-A1 NITROXY GROUP-CONTAINING BENZYLAMINE DERIVATIVES AND THEIR USE FOR TREATING CARDIOVASCULAR DISEASES, AS WELL AS INCREASED INTRA-OCULAR PRESSURE Byk Nederland BV (NL) 1996-11-06 EP disclosed
WO-1995019952-A1 NITROXY GROUP-CONTAINING BENZYLAMINE DERIVATIVES AND THEIR USE FOR TREATING CARDIOVASCULAR DISEASES, AS WELL AS INCREASED INTRA-OCULAR PRESSURE BYK NEDERLAND BV (NL) 1995-07-27 WO disclosed
US-5385922-A Cardiovascular and gastrointestinal disorders; antiischemic and cardiotonic agents CEDONA PHARMACEUTICALS B.V. (NL) 1995-01-31 US disclosed
US-5378718-A Cardiovascular activity, hypotensive CEDONA PHARMACEUTICALS B.V. (NL) 1995-01-03 US disclosed
EP-0547104-A1 THIAZOLIDIN DERIVATIVES CEDONA PHARMACEUTICALS B.V. (NL) 1993-06-23 EP disclosed
EP-0541634-A1 1,4-DIHYDROPYRIDINE DERIVATIVES CEDONA PHARMACEUTICALS B.V. (NL) 1993-05-19 EP disclosed
WO-1992004337-A1 THIAZOLIDIN DERIVATIVES CEDONA PHARMACEUTICALS BV (NL) 1992-03-19 WO disclosed
WO-1992002503-A1 NOVEL 1,4-DIHYDROPYRIDINE DERIVATIVES CEDONA PHARMACEUTICALS BV (NL) 1992-02-20 WO disclosed