Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 5/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.51 |
| ▸ | ADRA1B | P35368 | 5/20 | 0.51 |
| ▸ | DRD3 | P35462 | 13/20 | 0.49 |
| ▸ | DRD2 | P14416 | 13/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | THPO | P40225 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7401480 | 1.00 | ADRA1D (0.51) | ADRA1DADRA1AADRA1BDRD3DRD2 | |
| Hydrochloric Acid SCHEMBL7338544 | 0.89 | ADRA1D (0.49) | ADRA1DADRA1AADRA1BDRD3DRD2 | |
| Hydrochloric Acid SCHEMBL7338540 | 0.89 | ADRA1D (0.49) | ADRA1DADRA1AADRA1BDRD3DRD2 | |
| SCHEMBL7800006 | 0.88 | DRD3 (0.47) | ADRA1DADRA1AADRA1BDRD3DRD2 | |
| SCHEMBL7338343 | 0.88 | DRD3 (0.47) | ADRA1DADRA1AADRA1BDRD3DRD2 | |
| Hydrochloric Acid SCHEMBL7800055 | 0.87 | ADRA1D (0.56) | ADRA1DADRA1AADRA1BDRD3DRD2 | |
| Hydrochloric Acid SCHEMBL7800053 | 0.87 | ADRA1D (0.56) | ADRA1DADRA1AADRA1BDRD3DRD2 | |
| Hydrochloric Acid SCHEMBL7338339 | 0.86 | DRD2 (0.48) | ADRA1DADRA1AADRA1BDRD3DRD2 | |
| Hydrochloric Acid SCHEMBL7338342 | 0.86 | DRD2 (0.48) | ADRA1DADRA1AADRA1BDRD3DRD2 | |
| Hydrochloric Acid SCHEMBL7799038 | 0.86 | ADRA1D (0.59) | ADRA1DADRA1AADRA1BDRD3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0781126-B1 | DERIVATIVES OF 2-AMINO-1,2,3,4-TETRAHYDRO-NAPHTHALENE ACTIVE ON THE CARDIOVASCULAR SYSTEM | ZAMBON SPA (IT) | 2001-12-12 | — | — | EP | disclosed |
| EP-0781126-A2 | DERIVATIVES OF 2-AMINO-1,2,3,4-TETRAHYDRO-NAPHTHALENE ACTIVE ON THE CARDIOVASCULAR SYSTEM | ZAMBON GROUP S.p.A. (IT) | 1997-07-02 | — | — | EP | disclosed |
| WO-1996008228-A2 | DERIVATIVES OF 2-AMINO-1,2,3,4-TETRAHYDRO-NAPHTHALENE ACTIVE ON THE CARDIOVASCULAR SYSTEM | ZAMBON GROUP S.P.A. (IT) | 1996-03-21 | — | — | WO | disclosed |