Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 3/20 | 0.67 |
| ▸ | HTR3B | O95264 | 3/20 | 0.67 |
| ▸ | HTR3A | P46098 | 3/20 | 0.67 |
| ▸ | HTR3D | Q70Z44 | 3/20 | 0.67 |
| ▸ | HTR3C | Q8WXA8 | 3/20 | 0.67 |
| ▸ | HTR4 | Q13639 | 7/20 | 0.61 |
| ▸ | DRD2 | P14416 | 2/20 | 0.56 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MPO | P05164 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.53 |
| ▸ | DRD4 | P21917 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | HTR2C | P28335 | 1/20 | 0.53 |
| ▸ | DRD3 | P35462 | 1/20 | 0.53 |
| ▸ | HTR2B | P41595 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27003054 | 0.92 | HTR3E (0.63) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL27003043 | 0.91 | HCN4 (0.66) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL27003068 | 0.90 | HCN4 (0.66) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL27003060 | 0.90 | HTR3E (0.63) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL7397550 | 0.89 | HTR4 (0.67) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL27003056 | 0.89 | HTR3E (0.62) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL9474371 | 0.83 | HTR3E (0.64) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL10719821 | 0.82 | HTR3E (0.60) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL9458342 | 0.81 | HTR3E (0.62) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL16233228 | 0.80 | HTR3E (0.64) | HTR3EHTR3BHTR3AHTR3DHTR3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5612366-A | USEFUL IN TREATMENT OF CENTRAL NERVOUS SYSTEM AND GASTROINTESTINAL MOTILITY DISORDERS | G. D. SEARLE & CO. (US) | 1997-03-18 | — | — | US | disclosed |
| US-5516782-A | FOR TREATMENT OF ANXIETY, PSYCHOSES, DEPRESSION OR GASTROINTESTINAL MOTILITY DISTURBANCES | G. D. SEARLE & CO. (US) | 1996-05-14 | — | — | US | disclosed |
| US-5318977-A | New meso-azacyclic aromatic acid amides and esters as novel serotonergic agents | G. D. SEARLE & CO. (US) | 1994-06-07 | — | — | US | disclosed |
| EP-0504680-A1 | New meso-azacyclic aromatic acid amides and esters as novel serotonergic agents | G.D. Searle & Co. (US) | 1992-09-23 | — | — | EP | disclosed |
| WO-1992015590-A1 | NEW MESO-AZACYCLIC AROMATIC ACID AMIDES AND ESTERS AS NOVEL SEROTONERGIC AGENTS | G.D. SEARLE & CO. (US) | 1992-09-17 | — | — | WO | disclosed |