Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS4 | O75173 | 3/20 | 0.57 |
| ▸ | MMP3 | P08254 | 3/20 | 0.57 |
| ▸ | ADAMTS1 | Q9UHI8 | 3/20 | 0.57 |
| ▸ | ADAMTS5 | Q9UNA0 | 3/20 | 0.57 |
| ▸ | MMP8 | P22894 | 2/20 | 0.57 |
| ▸ | MMP10 | P09238 | 1/20 | 0.57 |
| ▸ | MMP14 | P50281 | 1/20 | 0.57 |
| ▸ | MMP15 | P51511 | 1/20 | 0.57 |
| ▸ | ADAM17 | P78536 | 17/20 | 0.54 |
| ▸ | MMP7 | P09237 | 2/20 | 0.52 |
| ▸ | MMP13 | P45452 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6597685 | 0.85 | ADAMTS4 (0.77) | ADAMTS4MMP3ADAMTS1ADAMTS5MMP8 | |
| SCHEMBL7401098 | 0.84 | ADAM17 (0.61) | ADAMTS4MMP3ADAMTS1ADAMTS5MMP8 | |
| SCHEMBL7399912 | 0.84 | ADAM17 (0.73) | ADAMTS4MMP3ADAMTS1ADAMTS5MMP8 | |
| SCHEMBL7401563 | 0.84 | ADAMTS4 (0.66) | ADAMTS4MMP3ADAMTS1ADAMTS5MMP8 | |
| SCHEMBL7404850 | 0.83 | ADAM17 (0.58) | ADAMTS4MMP3ADAMTS1ADAMTS5MMP8 | |
| SCHEMBL7397813 | 0.83 | ADAM17 (0.60) | ADAMTS4MMP3ADAMTS1ADAMTS5MMP8 | |
| SCHEMBL7402528 | 0.83 | ADAM17 (0.56) | ADAMTS4MMP3ADAMTS1ADAMTS5MMP8 | |
| SCHEMBL7399768 | 0.83 | ADAM17 (0.66) | ADAMTS4MMP3ADAMTS1ADAMTS5MMP8 | |
| SCHEMBL7403315 | 0.82 | ADAM17 (0.74) | ADAMTS4MMP3ADAMTS1ADAMTS5ADAM17 | |
| SCHEMBL7395058 | 0.82 | ADAM17 (0.57) | ADAMTS4MMP3ADAMTS1ADAMTS5MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1263756-A2 | BETA-AMINO ACID DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEASES AND TNF-ALPHA | Bristol-Myers Squibb Pharma Company (US) | 2002-12-11 | — | — | EP | claimed |
| WO-2001070734-A2 | BETA-AMINO ACID DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEASES AND TNF-ALPHA | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2001-09-27 | — | — | WO | claimed |