Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.57 |
| ▸ | MAPT | P10636 | 7/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.57 |
| ▸ | HPGD | P15428 | 6/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | KAT2A | Q92830 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL887866 | 0.89 | MAPT (0.53) | KDM4EMAPTALDH1A1HPGDSMN1; SMN2 | |
| Bromide SCHEMBL8625190 | 0.88 | MAPT (0.51) | KDM4EMAPTALDH1A1HPGDSMN1; SMN2 | |
| Bromide SCHEMBL2951033 | 0.83 | ALDH1A1 (0.60) | KDM4EMAPTALDH1A1HPGDSMN1; SMN2 | |
| Bromide SCHEMBL8390275 | 0.83 | ALDH1A1 (0.60) | KDM4EMAPTALDH1A1HPGDSMN1; SMN2 | |
| Bromide SCHEMBL8390272 | 0.82 | ALDH1A1 (0.58) | KDM4EMAPTALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL6936085 | 0.81 | ALDH1A1 (0.57) | KDM4EMAPTALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL1231696 | 0.79 | ALDH1A1 (0.58) | KDM4EMAPTALDH1A1HPGDSMN1; SMN2 | |
| Bromide SCHEMBL1947833 | 0.78 | KDM4E (0.61) | KDM4EMAPTALDH1A1HPGDSMN1; SMN2 | |
| Bromide SCHEMBL2954113 | 0.76 | KMT2A (0.55) | KDM4EMAPTALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL7994349 | 0.76 | KDM4E (0.44) | KDM4EMAPTALDH1A1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0748464-B1 | SENSITIZERS FOR PHOTOTHERMOGRAPHIC ELEMENTS | IMATION CORP A DELAWARE CORP (US) | 1998-06-24 | — | — | EP | disclosed |
| EP-0808163-A2 | USE OF THIAZOLIUM COMPOUNDS FOR PREVENTING AND REVERSING THE FORMATION OF ADVANCED GLYCOSYLATION ENDPRODUCTS | ALTEON, INC. (US) | 1997-11-26 | — | — | EP | disclosed |
| EP-0748464-A1 | SENSITIZERS FOR PHOTOTHERMOGRAPHIC ELEMENTS | Imation Corp (a Delaware Corporation) (US) | 1996-12-18 | — | — | EP | disclosed |
| WO-1996022095-A2 | USE OF THIAZOLIUM COMPOUNDS FOR PREVENTING AND REVERSING THE FORMATION OF ADVANCED GLYCOSYLATION ENDPRODUCTS | ALTEON INC. (US) | 1996-07-25 | — | — | WO | disclosed |
| WO-1995023355-A1 | SENSITIZERS FOR PHOTOTHERMOGRAPHIC ELEMENTS | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1995-08-31 | — | — | WO | disclosed |
| US-5441866-A | Benzothiazole-type cyanine dyes | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1995-08-15 | — | — | US | disclosed |