Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 2/20 | 0.41 |
| ▸ | CTSS | P25774 | 2/20 | 0.41 |
| ▸ | CTSK | P43235 | 2/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | AAK1 | Q2M2I8 | 5/20 | 0.37 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14779394 | 0.86 | CTSS (0.43) | CTSLCTSSCTSKCTSBCA1 | |
| SCHEMBL2732000 | 0.85 | TDP1 (0.35) | CTSLCTSSCTSKCTSBCA1 | |
| SCHEMBL835634 | 0.80 | CA12 (0.37) | CTSLCTSSCTSKCTSBCA1 | |
| SCHEMBL9410028 | 0.77 | CA1 (0.38) | CTSLCTSSCTSKCTSBCA1 | |
| SCHEMBL15254162 | 0.77 | CA1 (0.38) | CTSLCTSSCTSKCTSBCA1 | |
| SCHEMBL531844 | 0.76 | CTSS (0.48) | CTSLCTSSCTSKCTSBCA1 | |
| SCHEMBL30700177 | 0.74 | CTSS (0.47) | CTSLCTSSCTSKCTSBCA1 | |
| SCHEMBL30699928 | 0.74 | CTSS (0.47) | CTSLCTSSCTSKCTSBCA1 | |
| SCHEMBL30699931 | 0.74 | CTSS (0.47) | CTSLCTSSCTSKCTSBCA1 | |
| SCHEMBL6344379 | 0.74 | CTSS (0.39) | CTSLCTSSCTSKCTSBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0618221-A2 | Heterocyclic inhibitors of farnesyl protein transferase | BRISTOL-MYERS SQUIBB COMPANY (US) | 1994-10-05 | — | — | EP | disclosed |
| US-4885292-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1989-12-05 | — | — | US | disclosed |
| EP-0231919-A2 | N-Heterocyclic alcohol renin inhibitors | E.R. Squibb & Sons, Inc. (US) | 1987-08-12 | — | — | EP | disclosed |