Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 12/20 | 0.55 |
| ▸ | PDE4A | P27815 | 12/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 12/20 | 0.55 |
| ▸ | PDE4C | Q08493 | 12/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 12/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7395398 | 0.86 | PDE5A (0.49) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7400772 | 0.80 | PDE5A (0.65) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7401994 | 0.74 | PDE5A (0.42) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7400872 | 0.71 | PDE5A (1.00) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7446384 | 0.69 | PDE5A (1.00) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7399841 | 0.69 | PDE5A (0.61) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7400585 | 0.67 | PDE4A (1.00) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL25235156 | 0.65 | PDE5A (0.60) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL25222680 | 0.64 | PDE5A (0.59) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL24769075 | 0.64 | LMNA (0.60) | CYP2C19ALDH1A1LMNAHTTATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0641344-A1 | 8-SUBSTITUTED ANTHINES AS PHOSPHODIESTERASE INHIBITORS | SMITHKLINE BEECHAM PLC (GB) | 1995-03-08 | — | — | EP | disclosed |
| WO-1993023401-A1 | 8-SUBSTITUTED ANTHINES AS PHOSPHODIESTERASE INHIBITORS | SMITHKLINE BEECHAM PLC (GB) | 1993-11-25 | — | — | WO | disclosed |