Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 6/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | STAT1 | P42224 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7404074 | 0.83 | LDHA (0.43) | KMT2ARAB9ANPC1ALDH1A1LMNA | |
| SCHEMBL6068448 | 0.78 | TDP1 (0.59) | TDP1KMT2ASLC6A2SLC6A3TSHR | |
| SCHEMBL21396290 | 0.77 | TDP1 (0.54) | TDP1KMT2ASLC6A2SLC6A3TSHR | |
| SCHEMBL7323211 | 0.76 | TDP1 (0.53) | TDP1KMT2ASLC6A2SLC6A3TSHR | |
| SCHEMBL26390430 | 0.76 | TDP1 (0.53) | TDP1KMT2ASLC6A2SLC6A3TSHR | |
| SCHEMBL5935183 | 0.75 | TDP1 (0.56) | TDP1KMT2ASLC6A2SLC6A3TSHR | |
| SCHEMBL31636376 | 0.75 | TDP1 (0.59) | TDP1KMT2ASLC6A2SLC6A3TSHR | |
| SCHEMBL10760609 | 0.74 | TDP1 (0.54) | TDP1KMT2ASLC6A2SLC6A3TSHR | |
| SCHEMBL3981567 | 0.74 | RAB9A (0.49) | TDP1KMT2ASLC6A2SLC6A3TSHR | |
| SCHEMBL8665006 | 0.74 | TDP1 (0.47) | TDP1KMT2ASLC6A2SLC6A3TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0765340-B1 | METHIONINE SULFONE AND S-SUBSTITUTED CYSTEINE SULFONE DERIVATIVES AS ENZYME INHIBITORS | CORVAS INT INC (US) | 2000-08-30 | — | — | EP | disclosed |
| US-5658939-A | PREVENTION THROMBOSIS IN MAMMALS | CORVAS INTERNATIONAL INC. (US) | 1997-08-19 | — | — | US | disclosed |
| EP-0765340-A1 | METHIONINE SULFONE AND S-SUBSTITUTED CYSTEINE SULFONE DERIVATIVES AS ENZYME INHIBITORS | CORVAS INTERNATIONAL, INC. (US) | 1997-04-02 | — | — | EP | disclosed |
| WO-1995028420-A1 | METHIONINE SULFONE AND S-SUBSTITUTED CYSTEINE SULFONE DERIVATIVES AS ENZYME INHIBITORS | CORVAS INTERNATIONAL, INC. (US) | 1995-10-26 | — | — | WO | disclosed |