Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | THRB | P10828 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | GSK3A | P49840 | 2/20 | 0.41 |
| ▸ | GSK3B | P49841 | 2/20 | 0.41 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL964206 | 0.76 | ALDH1A1 (1.00) | ALDH1A1GAATHRBKDM4ELMNA | |
| SCHEMBL15057965 | 0.74 | ALDH1A1 (0.64) | ALDH1A1GAATHRBKDM4ELMNA | |
| SCHEMBL1461002 | 0.73 | GAA (0.37) | ALDH1A1GAATHRBKDM4ETDP1 | |
| SCHEMBL178857 | 0.72 | LOX (0.71) | ALDH1A1GAAKDM4ETDP1MEN1 | |
| SCHEMBL3529328 | 0.72 | ALDH1A1 (0.60) | ALDH1A1GAATHRBKDM4ELMNA | |
| SCHEMBL1754745 | 0.67 | PGR (0.75) | ALDH1A1GAATHRBKDM4ELMNA | |
| SCHEMBL10080903 | 0.66 | GAA (0.64) | ALDH1A1GAATHRBKDM4ELMNA | |
| SCHEMBL359249 | 0.66 | ALDH1A1 (0.56) | ALDH1A1GAATHRBKDM4ELMNA | |
| SCHEMBL359250 | 0.66 | ALDH1A1 (0.56) | ALDH1A1GAATHRBKDM4ELMNA | |
| SCHEMBL1758434 | 0.66 | KDM4E (0.72) | ALDH1A1GAATHRBKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5750550-A | RESPIRATORY SYSTEM DISORDERS | SANOFI (FR) | 1998-05-12 | — | — | US | disclosed |
| WO-1997010243-A1 | 2-(PYRAZOL-5-YL-OXYMETHYL)-1,2-BENZISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SANOFI (US) | 1997-03-20 | — | — | WO | disclosed |