Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 3/20 | 0.42 |
| ▸ | HTR2A | P28223 | 3/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | BCL9 | O00512 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23581472 | 0.85 | KDM4E (0.41) | SMN1; SMN2ALDH1A1KMT2AL3MBTL1MEN1 | |
| SCHEMBL8500693 | 0.81 | MAPT (0.44) | DRD1DRD2SMN1; SMN2LMNANPC1 | |
| SCHEMBL27799151 | 0.80 | HTR1A (0.35) | DRD1HTR2ADRD2HTR1ALMNA | |
| SCHEMBL27584431 | 0.78 | MAPT (0.38) | SMN1; SMN2LMNANPC1ALDH1A1KMT2A | |
| SCHEMBL27532472 | 0.76 | MAPT (0.46) | SMN1; SMN2LMNAGAANPC1ALDH1A1 | |
| SCHEMBL13160775 | 0.75 | MAPT (0.35) | SMN1; SMN2LMNAGAAALDH1A1KMT2A | |
| SCHEMBL27602229 | 0.74 | MAPT (0.43) | SMN1; SMN2LMNAGAANPC1RAB9A | |
| SCHEMBL8927841 | 0.74 | SMN1; SMN2 (0.40) | DRD1HTR2ADRD2HTR1ASMN1; SMN2 | |
| SCHEMBL1182305 | 0.73 | MAPT (0.42) | SMN1; SMN2LMNANPC1RAB9AALDH1A1 | |
| SCHEMBL27481662 | 0.72 | CES1 (0.36) | SMN1; SMN2LMNAGAANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101429125-A | Synthesis of (7-methoxy-3, 4-dihydrogen-1-naphthyl) ethyl acetate | SHANGHAI INST PHARM INDUSTRY (CN) | 2009-05-13 | — | — | CN | disclosed |
| US-6133446-A | Heterocyclic compounds for the treatment of CNS and cardiovascular disorders | PHARMACIA & UPJOHN COMPANY (US) | 2000-10-17 | — | — | US | disclosed |
| CN-1046507-C | Heterocyclic compounds for the treatment of central nervous system and cardiovascular diseases | UPJOHN CO (US) | 1999-11-17 | — | — | CN | disclosed |
| US-5877317-A | Heterocyclic compounds for the treatment of CNS and cardiovascular disorders | PHARMACIA & UPJOHN COMPANY (US) | 1999-03-02 | — | — | US | disclosed |
| CN-1139431-A | Heterocyclic compounds for the treatment of central nervous system and cardiovascular diseases | PHARMACIA & UPJOHN CO LLC (US) | 1997-01-01 | — | — | CN | disclosed |
| WO-1995018118-A1 | HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF CNS AND CARDIOVASCULAR DISORDERS | THE UPJOHN COMPANY (US) | 1995-07-06 | — | — | WO | disclosed |