Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1B | P49286 | 3/20 | 0.51 |
| ▸ | DRD2 | P14416 | 2/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.48 |
| ▸ | PLAU | P00749 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | IDE | P14735 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3680265 | 0.83 | HRH4 (0.61) | DRD2DRD3PLAULMNAALDH1A1 | |
| SCHEMBL1775059 | 0.81 | HCAR2 (0.46) | PDGFRBPLAUHCAR2LMNAALDH1A1 | |
| SCHEMBL17844916 | 0.81 | HCAR2 (0.46) | PDGFRBHCAR2KDM4EHRH4 | |
| SCHEMBL3678516 | 0.80 | LRRK2 (0.50) | MTNR1BDRD2DRD3PLAUDRD4 | |
| Trifluoroacetic Acid SCHEMBL30619102 | 0.80 | NCF1 (0.50) | DRD2DRD3PLAUHRH4 | |
| SCHEMBL3678007 | 0.80 | NCF1 (0.61) | DYRK1A | |
| SCHEMBL1729130 | 0.77 | ENPP1 (0.51) | MTNR1BDRD2DRD3DRD4 | |
| SCHEMBL1775392 | 0.77 | HCAR2 (0.43) | PDGFRBPLAUHCAR2LMNAALDH1A1 | |
| SCHEMBL27626446 | 0.77 | HCAR2 (0.41) | HCAR2HRH4 | |
| SCHEMBL27626531 | 0.77 | HCAR2 (0.41) | HCAR2HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0971928-A1 | QUINOLINE-2(1H)-ONE AND DIHYDROQUINOLINE-2(1H)-ONE DERIVATIVES AS LIGANDS OF 5-HT, 5-HT2 AND 5-HT1-LIKE RECEPTORS | SANOFI-SYNTHELABO (FR) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998042712-A1 | QUINOLINE-2(1H)-ONE AND DIHYDROQUINOLINE-2(1H)-ONE DERIVATIVES AS LIGANDS OF 5-HT, 5-HT2 AND 5-HT1-LIKE RECEPTORS | SANOFI-SYNTHELABO (FR) | 1998-10-01 | — | — | WO | disclosed |