Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.45 |
| ▸ | NPC1 | O15118 | 6/20 | 0.45 |
| ▸ | RAB9A | P51151 | 6/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.43 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.42 |
| ▸ | CHUK | O15111 | 1/20 | 0.41 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.41 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9948682 | 0.79 | NOTUM (0.45) | L3MBTL1NPC1RAB9ATDP1NPSR1 | |
| SCHEMBL9949734 | 0.79 | NPC1 (0.44) | L3MBTL1NPC1RAB9ATDP1NPSR1 | |
| SCHEMBL13232016 | 0.79 | L3MBTL1 (0.44) | L3MBTL1NPC1RAB9ATDP1NPSR1 | |
| SCHEMBL7394051 | 0.78 | TDP1 (0.54) | L3MBTL1NPC1RAB9ATDP1SMN1; SMN2 | |
| SCHEMBL2094070 | 0.78 | NOTUM (0.62) | L3MBTL1NPC1RAB9ATDP1SMN1; SMN2 | |
| SCHEMBL14600787 | 0.76 | BCHE (0.46) | L3MBTL1NPC1RAB9ASMN1; SMN2BCHE | |
| SCHEMBL5334470 | 0.75 | ACHE (0.56) | L3MBTL1NPC1RAB9ANPSR1SMN1; SMN2 | |
| SCHEMBL2062074 | 0.74 | ACHE (0.53) | L3MBTL1NPC1RAB9ATDP1SMN1; SMN2 | |
| SCHEMBL9949703 | 0.72 | PPARG (0.46) | L3MBTL1NPC1RAB9ATDP1NPSR1 | |
| SCHEMBL8402282 | 0.71 | CHUK (0.40) | L3MBTL1NPC1RAB9ATDP1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0419397-B1 | Substituted urea compounds and their preparation and use | NOVO NORDISK AS (DK) | 1994-06-08 | — | — | EP | claimed |
| US-5330990-A | Antagonists of 5-HT and 5-HT3 receptors, psychological disorders, antinausea | NOVO NORDISK A/S (DK) | 1994-07-19 | — | — | US | disclosed |
| EP-0419397-B1 | Substituted urea compounds and their preparation and use | NOVO NORDISK AS (DK) | 1994-06-08 | — | — | EP | disclosed |
| EP-0491770-A1 | SUBSTITUTED UREA COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1992-07-01 | — | — | EP | disclosed |
| EP-0419397-A1 | Substituted urea compounds and their preparation and use | NOVO NORDISK A/S (DK) | 1991-03-27 | — | — | EP | disclosed |
| WO-1991003475-A1 | SUBSTITUTED UREA COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1991-03-21 | — | — | WO | disclosed |