Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | COMT | P21964 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31056505 | 0.84 | SMN1; SMN2 (0.50) | COMTSMN1; SMN2ALDH1A1KDM4EPOLB | |
| SCHEMBL22367839 | 0.84 | GRIN2D (0.40) | GAACOMTSMN1; SMN2ALDH1A1PDGFRB | |
| SCHEMBL7407394 | 0.83 | GAA (0.46) | GAACOMTSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL7405341 | 0.80 | GAA (0.46) | GAAALDH1A1KDM4EPOLBMAPT | |
| SCHEMBL7409820 | 0.80 | SMN1; SMN2 (0.40) | GAACOMTSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL1457871 | 0.79 | GAA (0.44) | GAASMN1; SMN2ALDH1A1CYP3A4KDM4E | |
| SCHEMBL28740427 | 0.79 | SMN1; SMN2 (0.41) | GAACOMTSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL31156079 | 0.78 | SMN1; SMN2 (0.41) | GAACOMTSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL28418045 | 0.77 | SOS1 (0.44) | GAACOMTSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL11430270 | 0.77 | ALDH1A1 (0.54) | GAASMN1; SMN2ALDH1A1CYP3A4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4935511-A | Nervous system, gastrointestinal disorders | RORER PHARMACEUTICAL CORPORATION (US) | 1990-06-19 | — | — | US | disclosed |