Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNMT1 | P26358 | 4/20 | 0.61 |
| ▸ | DNMT3A | Q9Y6K1 | 4/20 | 0.61 |
| ▸ | CLK1 | P49759 | 1/20 | 0.61 |
| ▸ | HTR2C | P28335 | 8/20 | 0.58 |
| ▸ | HTR2B | P41595 | 8/20 | 0.58 |
| ▸ | DNMT3L | Q9UJW3 | 3/20 | 0.53 |
| ▸ | EHMT1 | Q9H9B1 | 2/20 | 0.53 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.52 |
| ▸ | GSK3A | P49840 | 2/20 | 0.51 |
| ▸ | GSK3B | P49841 | 2/20 | 0.51 |
| ▸ | PLK4 | O00444 | 1/20 | 0.51 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.51 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.51 |
| ▸ | CDK1 | P06493 | 1/20 | 0.51 |
| ▸ | PIM1 | P11309 | 1/20 | 0.51 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7660465 | 0.99 | DNMT1 (0.60) | DNMT1DNMT3ACLK1HTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL7661070 | 0.88 | CLK1 (0.61) | DNMT1DNMT3ACLK1HTR2CHTR2B | |
| Dimethylamine SCHEMBL7660199 | 0.82 | HTR2C (0.72) | DNMT1DNMT3AHTR2CHTR2BDNMT3L | |
| Hydrochloric Acid SCHEMBL7652839 | 0.81 | MAPT (0.60) | HTR2CHTR2BTRPV1CYP3A4MEN1 | |
| Dimethylamine SCHEMBL7661486 | 0.81 | HTR2C (0.70) | DNMT1DNMT3AHTR2CHTR2BDNMT3L | |
| SCHEMBL3807061 | 0.81 | HTR2C (0.73) | DNMT1DNMT3AHTR2CHTR2BDNMT3L | |
| SCHEMBL7371691 | 0.81 | HTR2C (0.59) | DNMT1DNMT3ACLK1HTR2CHTR2B | |
| SCHEMBL7371124 | 0.81 | FADS1 (0.67) | HTR2CHTR2BTRPV1GSK3AGSK3B | |
| SCHEMBL7447310 | 0.80 | HTR2C (0.67) | HTR2CHTR2BTRPV1GSK3AGSK3B | |
| SCHEMBL7447576 | 0.80 | HTR2C (0.63) | HTR2CHTR2BTRPV1GSK3AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003737-A1 | PHENYL UREA AND PHENYL THIOUREA DERIVATIVES AS HFGAN72 ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2000-05-31 | — | — | EP | disclosed |
| WO-1999009024-A1 | PHENYL UREA AND PHENYL THIOUREA DERIVATIVES AS HFGAN72 ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1999-02-25 | — | — | WO | disclosed |