Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 8/20 | 0.63 |
| ▸ | HTR2B | P41595 | 8/20 | 0.63 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.53 |
| ▸ | GSK3A | P49840 | 3/20 | 0.53 |
| ▸ | GSK3B | P49841 | 3/20 | 0.53 |
| ▸ | KIT | P10721 | 3/20 | 0.53 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.53 |
| ▸ | CDK8 | P49336 | 2/20 | 0.53 |
| ▸ | MST1R | Q04912 | 1/20 | 0.53 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.53 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.53 |
| ▸ | KDR | P35968 | 3/20 | 0.52 |
| ▸ | PLK4 | O00444 | 1/20 | 0.52 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.52 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.52 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.52 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.52 |
| ▸ | CDK1 | P06493 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7373725 | 0.86 | HTR2C (0.74) | HTR2CHTR2BMAPTCLK4GSK3A | |
| Hydrochloric Acid SCHEMBL7658357 | 0.83 | HTR2C (0.59) | HTR2CHTR2BMAPTCLK4GSK3A | |
| Hydrochloric Acid SCHEMBL7652839 | 0.82 | MAPT (0.60) | HTR2CHTR2BMAPTTRPV1MEN1 | |
| Hydrochloric Acid SCHEMBL7661070 | 0.82 | CLK1 (0.61) | HTR2CHTR2BMAPTCLK4GSK3A | |
| SCHEMBL7455693 | 0.82 | SMN1; SMN2 (0.58) | HTR2CHTR2BTRPV1MEN1NPC1 | |
| SCHEMBL3807061 | 0.82 | HTR2C (0.73) | HTR2CHTR2BMAPTCLK4GSK3A | |
| SCHEMBL7371691 | 0.81 | HTR2C (0.59) | HTR2CHTR2BCLK4GSK3AGSK3B | |
| SCHEMBL7371124 | 0.81 | FADS1 (0.67) | HTR2CHTR2BMAPTCLK4GSK3A | |
| Hydrochloric Acid SCHEMBL7657697 | 0.81 | SMN1; SMN2 (0.57) | HTR2CHTR2BTRPV1MEN1NPC1 | |
| SCHEMBL7447310 | 0.81 | HTR2C (0.67) | HTR2CHTR2BMAPTCLK4GSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6410529-B1 | DIETETICS; NON-INSULIN DEPENDENT DIABETES; SLEEP DISORDERS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-06-25 | — | — | US | claimed |
| US-6410529-B1 | DIETETICS; NON-INSULIN DEPENDENT DIABETES; SLEEP DISORDERS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-06-25 | — | — | US | disclosed |
| EP-1003737-A1 | PHENYL UREA AND PHENYL THIOUREA DERIVATIVES AS HFGAN72 ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2000-05-31 | — | — | EP | disclosed |
| WO-1999009024-A1 | PHENYL UREA AND PHENYL THIOUREA DERIVATIVES AS HFGAN72 ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1999-02-25 | — | — | WO | disclosed |