SCHEMBL7404694

SCHEMBL7404694

CC(C)[C@H](N)c1nc2ccccc2[nH]1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 1/20 0.64
ALDH1A1 P00352 3/20 0.58
POLB P06746 2/20 0.58
IDO1 P14902 1/20 0.58
MLKL Q8NB16 3/20 0.54
KMT2A Q03164 3/20 0.49
ALOX12 P18054 1/20 0.49
MASP2 O00187 1/20 0.48
MEN1 O00255 1/20 0.48
NUDT1 P36639 1/20 0.48
AOC3 Q16853 1/20 0.48
ALPL P05186 1/20 0.48
MAPK1 P28482 1/20 0.48
SCN10A Q9Y5Y9 3/20 0.48
KDM4E B2RXH2 1/20 0.47
NPC1 O15118 1/20 0.47
ABCB11 O95342 1/20 0.47
TP53 P04637 1/20 0.47
PKM P14618 1/20 0.47
RAB9A P51151 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12737571 0.85 TAAR1 (0.68) TAAR1ALDH1A1POLBIDO1MLKL
SCHEMBL8330903 0.85 TAAR1 (0.68) TAAR1ALDH1A1POLBIDO1MLKL
SCHEMBL524001 0.85 TAAR1 (0.68) TAAR1ALDH1A1POLBIDO1MLKL
Hydrochloric Acid SCHEMBL2452918 0.84 TAAR1 (0.66) TAAR1ALDH1A1POLBIDO1MLKL
Hydrochloric Acid SCHEMBL5207771 0.82 TAAR1 (0.64) TAAR1ALDH1A1POLBIDO1MLKL
SCHEMBL23181664 0.81 POLB (0.61) TAAR1ALDH1A1POLBIDO1MLKL
SCHEMBL21180833 0.81 POLB (0.61) TAAR1ALDH1A1POLBIDO1MLKL
SCHEMBL85832 0.81 ALDH1A1 (0.66) TAAR1ALDH1A1POLBIDO1MLKL
SCHEMBL30665026 0.81 ALDH1A1 (0.66) TAAR1ALDH1A1POLBIDO1MLKL
SCHEMBL2147079 0.81 ALDH1A1 (0.66) TAAR1ALDH1A1POLBIDO1MLKL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5733882-A Retroviral protease inhibitors SMITHKLINE BEECHAM CORPORATION (US) 1998-03-31 US disclosed
EP-0602069-A4 RETROVIRAL PROTEASE INHIBITORS. SMITHKLINE BEECHAM CORP (US) 1995-05-03 EP disclosed
EP-0602069-A1 RETROVIRAL PROTEASE INHIBITORS SMITHKLINE BEECHAM CORPORATION (US) 1994-06-22 EP disclosed
WO-1993002057-A1 RETROVIRAL PROTEASE INHIBITORS SMITHKLINE BEECHAM CORPORATION (US) 1993-02-04 WO disclosed