Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | IDO1 | P14902 | 1/20 | 0.61 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.58 |
| ▸ | MLKL | Q8NB16 | 3/20 | 0.57 |
| ▸ | ALPL | P05186 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23181664 | 1.00 | POLB (0.61) | POLBALDH1A1IDO1TAAR1MLKL | |
| SCHEMBL85832 | 0.84 | ALDH1A1 (0.66) | POLBALDH1A1IDO1TAAR1MLKL | |
| SCHEMBL30665026 | 0.84 | ALDH1A1 (0.66) | POLBALDH1A1IDO1TAAR1MLKL | |
| SCHEMBL2147079 | 0.84 | ALDH1A1 (0.66) | POLBALDH1A1IDO1TAAR1MLKL | |
| SCHEMBL30430265 | 0.83 | KMT2A (0.61) | POLBALDH1A1IDO1TAAR1MLKL | |
| SCHEMBL7404694 | 0.81 | TAAR1 (0.64) | POLBALDH1A1IDO1TAAR1MLKL | |
| SCHEMBL13233277 | 0.81 | POLB (0.58) | POLBALDH1A1IDO1TAAR1MLKL | |
| SCHEMBL15221577 | 0.81 | IDO1 (0.79) | POLBALDH1A1IDO1TAAR1MLKL | |
| SCHEMBL9675207 | 0.81 | POLB (0.72) | POLBALDH1A1IDO1TAAR1MLKL | |
| SCHEMBL22761575 | 0.81 | POLB (0.61) | POLBALDH1A1IDO1TAAR1MLKL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10358427-B2 | Modulators of indoleamine 2,3-dioxygenase | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-07-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10358427-B2 | Modulators of indoleamine 2,3-dioxygenase | IDO1, IDO2, INMT | POLB 3497/4885ALDH1A1 978/4885IDO1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.