Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 known ✓ | Q99720 | 2/20 | 0.72 |
| ▸ | SLC6A2 known ✓ | P23975 | 3/20 | 0.57 |
| ▸ | SLC6A4 known ✓ | P31645 | 3/20 | 0.57 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.53 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.72 |
| ▸ | DRD4 | P21917 | 1/20 | 0.60 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7408986 | 0.99 | TMEM97 (0.73) | TMEM97SIGMAR1DRD4HRH3SLC6A2 | |
| Bromide SCHEMBL7398424 | 0.90 | TMEM97 (0.71) | TMEM97SIGMAR1DRD4SLC6A2SLC6A4 | |
| SCHEMBL7397301 | 0.89 | TMEM97 (0.73) | TMEM97SIGMAR1DRD4SLC6A2SLC6A4 | |
| SCHEMBL5888823 | 0.84 | SIGMAR1 (1.00) | TMEM97SIGMAR1DRD4HRH3SLC6A2 | |
| Bromide SCHEMBL7404879 | 0.83 | LTA4H (0.56) | TMEM97SIGMAR1DRD4MEN1KMT2A | |
| Bromide SCHEMBL7405545 | 0.83 | SIGMAR1 (0.65) | TMEM97SIGMAR1DRD4MEN1KMT2A | |
| Bromide SCHEMBL8169444 | 0.82 | SIGMAR1 (0.81) | TMEM97SIGMAR1DRD4HRH3SLC6A2 | |
| SCHEMBL7405430 | 0.82 | MEN1 (0.58) | TMEM97SIGMAR1DRD4HRH3MEN1 | |
| SCHEMBL7407297 | 0.82 | SIGMAR1 (0.66) | TMEM97SIGMAR1DRD4MEN1KMT2A | |
| SCHEMBL7397982 | 0.82 | LTA4H (0.57) | TMEM97SIGMAR1DRD4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6124323-A | ACTIVE DRUG TREATING STROKE, CEREBRAL ISCHEMIA, CENTRAL NERVOUS SYSTEM TRAUMA, HYPOGLYCEMIA, ANXIETY, CONVULSIONS, AMIOGLYCOSIDE ANTIBIOTICS-INDUCED HEARING LOSS, MIGRAINE HEADACHES, CHRONIC PAIN, GLAUCOMA, CMV RETINITIS, PSYCHOSIS | WARNER-LAMBERT COMPANY (US) | 2000-09-26 | — | — | US | disclosed |
| EP-0869792-A4 | 4-SUBSTITUTED PIPERIDINE ANALOGS AND THEIR USE AS SUBTYPE SELECTIVE NMDA RECEPTOR ANTAGONISTS | WARNER LAMBERT CO (US) | 1999-09-22 | — | — | EP | disclosed |
| EP-0869792-A2 | 4-SUBSTITUTED PIPERIDINE ANALOGS AND THEIR USE AS SUBTYPE SELECTIVE NMDA RECEPTOR ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1998-10-14 | — | — | EP | disclosed |
| WO-1997023216-A1 | 4-SUBSTITUTED PIPERIDINE ANALOGS AND THEIR USE AS SUBTYPE SELECTIVE NMDA RECEPTOR ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1997-07-03 | — | — | WO | disclosed |